The Structural Genomics Centers for Infectious Diseases (SGCID) apply state-of-the-art high-throughput technologies and methodologies to experimentally characterize the three dimensional (3-D) atomic structure of proteins or other molecules that play an important biological role in human pathogens and infectious diseases, especially those in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The SGCID Centers conduct studies for characterizing molecular functions and biochemical properties of selected targets and structure-guided design and functional evaluation of drug targets and vaccine candidates.
Main Areas of Focus
The Centers provide the research community with
- Experimental 3-D protein structures and protein-ligand complexes (X-ray, NMR, CryoEM structures of NIAID category A-C priority agents and organisms causing emerging and re-emerging infectious diseases). 3-D structures and target lists can be found at:
- Sequence-verified clones, and peptides.
- Services that deliver requested 3-D structure determination.
- Molecular screening of proteins in complex with inhibitors, cofactors and substrate analogs
Novel Allosteric Inhibitor of Tryptophan Synthase – a New Target for Tuberculosis Therapeutics: An interdisciplinary team of scientists has investigated synthesis of tryptophan in Mycobacterium tuberculosis (MTB) as a pathway with potential therapeutic importance.