Structural Genomics Centers for Infectious Diseases

The Structural Genomics Centers for Infectious Diseases (SGCID) apply state-of-the-art high-throughput technologies and methodologies to experimentally characterize the three dimensional (3-D) atomic structure of proteins or other molecules that play an important biological role in human pathogens and infectious diseases, especially those in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The SGCID Centers conduct studies for characterizing molecular functions and biochemical properties of selected targets and structure-guided design and functional evaluation of drug targets and vaccine candidates. Collectively the SGCID centers have deposited over 2100 structures in the Protein Data Bank.

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The Centers provide the research community with

Featured Structure

CryoEM and X-ray structures shed light on the mechanism of Epstein-Barr Virus neutralizing antibody AMMO1: Infecting more than 95 percent of adults, Epstein-Barr virus (EBV) is part of the Herpesviridae family of DNA viruses. Primary infection by EBV often starts asymptomatically in children but can manifest into lymphoproliferative (excess white blood cell) disorders. In young adults, EBV is most widely known as the causative agent of infectious mononucleosis, or the ‘kissing disease’. Due to links to various forms of cancer, strategies for prevention of EBV infection are greatly needed.

Content last reviewed on October 18, 2018