Structural Genomics Centers for Infectious Diseases

NIAID-funded investigators at the SSGCID determined the structure and function of the SARS-CoV-2 spike glycoprotein. The findings were made available in the Protein Data Bank and published in Cell.

Credit: SSGCID

The Structural Genomics Centers for Infectious Diseases (SGCID) apply state-of-the-art high-throughput technologies and methodologies including computational modeling, x-ray crystallography, NMR and cryo EM to experimentally characterize the three dimensional (3-D) atomic structure of proteins that play an important biological role in human pathogens and infectious diseases, especially those in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The SGCID Centers conduct studies for characterizing molecular functions and biochemical properties of selected targets that address NIAID priorities and perform structure-guided design and drug discovery on vaccine and therapeutic candidates. The SGCIDs provide structure determination services to the scientific community and make available resources including structure information and resources. Collectively the SGCID centers have deposited almost 2400 structures in the Protein Data Bank. 

In addition to ongoing research efforts, the Structural Genomics Centers are actively responding to the COVID-19 outbreak. Their research has led to an improved understanding of the structure and function of SARS-CoV-2, and is helping to determine the effectiveness of existing therapeutics and identify new targets for drugs and vaccines. Investigators are making their findings rapidly available to the scientific community through public databases, including the Protein Data Bank.

For information on how to request services from the Centers, please see the Structural Genomics Resources for Researchers.

Locations

 

Contact Information

Main Areas of Focus

The Centers provide the research community with

  • Experimental 3-D protein structures and protein-ligand complexes (X-ray, NMR, CryoEM structures of NIAID category A-C priority agents and organisms causing emerging and re-emerging infectious diseases). 3-D structures and target lists can be found at:
  • Sequence-verified clones, and peptides.
  • Services that deliver requested 3-D structure determination.
  • Molecular screening of proteins in complex with inhibitors, cofactors and substrate analogs

SARS-CoV-2 Updates

The SSGCID and CSGID are making their data publicly available. For more information please see: SSGCID updates: https://www.ssgcid.org/sars-cov-2/ and the CSGID website: https://csgid.org/.

News and Announcements

 

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