Structural Genomics Centers for Infectious Diseases

NIAID-funded investigators at the SSGCID determined the structure and function of the SARS-CoV-2 spike glycoprotein. The findings were made available in the Protein Data Bank and published in Cell.

Credit: SSGCID

The Structural Genomics Centers characterize the 3D structure of proteins of infectious disease pathogens. Each Center is a collaborative effort consisting of teams from multiple academic institutions/companies. Protein structures are requested by NIAID or the extramural research community and are made publicly available through online databases such as the Protein Data Bank. The structures help investigators better understand pathogen activity on a molecular level and assist in the identification of targets for drugs, vaccines, and other medical countermeasures.

COVID-19 Research Activities

Both Centers have been at the forefront of COVID-19 basic and preclinical research activities. They have solved the structures of numerous SARS-CoV-2 proteins of high interest, including the spike protein, and have contributed substantially to the number of SARS-CoV-2 structures currently available in the Protein Data Bank. These efforts have provided critical insights into the molecular structure and mechanistic functions of SARS-CoV-2. In addition, both Centers have been active in efforts to identify and develop novel therapeutics, vaccines, and diagnostics for COVID-19. They have shown how different therapeutics bind to SARS-CoV-2, and have conducted preclinical screening to identify approved and candidate therapeutics with activity against SARS-CoV-2. They are using computational methods to facilitate the development of diagnostics and have been instrumental in structure-based vaccine design activities and efforts to determine correlates of protection for COVID-19.

Request Services

For information on how to request services from the Centers, please see the Structural Genomics Resources for Researchers.

Center Locations

Contact Information

Main Areas of Focus

The Centers provide the research community with

  • Experimental 3-D protein structures and protein-ligand complexes (X-ray, NMR, CryoEM structures of NIAID category A-C priority agents and organisms causing emerging and re-emerging infectious diseases). 3-D structures and target lists can be found at:
  • Sequence-verified clones, and peptides.
  • Services that deliver requested 3-D structure determination.
  • Molecular screening of proteins in complex with inhibitors, cofactors and substrate analogs
Content last reviewed on