The Structural Genomics Centers for Infectious Diseases (SGCID) apply state-of-the-art high-throughput technologies and methodologies to experimentally characterize the three dimensional (3-D) atomic structure of proteins or other molecules that play an important biological role in human pathogens and infectious diseases, especially those in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The SGCID Centers conduct studies for characterizing molecular functions and biochemical properties of selected targets and structure-guided design and functional evaluation of drug targets and vaccine candidates. Collectively the SGCID centers have deposited over 2100 structures in the Protein Data Bank.
Main Areas of Focus
The Centers provide the research community with
- Experimental 3-D protein structures and protein-ligand complexes (X-ray, NMR, CryoEM structures of NIAID category A-C priority agents and organisms causing emerging and re-emerging infectious diseases). 3-D structures and target lists can be found at:
- Sequence-verified clones, and peptides.
- Services that deliver requested 3-D structure determination.
- Molecular screening of proteins in complex with inhibitors, cofactors and substrate analogs