LJI Scientists Confirm Smallpox Vaccine Also Teaches T Cells to fight mpox

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La Jolla Institute for Immunology
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LJI Scientists Confirm Smallpox Vaccine Also Teaches T Cells to fight mpox
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UNMC to Participate in Trial of Possible Monkeypox Treatment

UC San Diego Joins National Trial to Test Drug for Treating MPOX

Monkeypox Treatment Trial Begins in the Democratic Republic of the Congo

A clinical trial to evaluate the antiviral drug tecovirimat, also known as TPOXX, in adults and children with monkeypox has begun in the Democratic Republic of the Congo (DRC). The trial will evaluate the drug’s safety and its ability to mitigate monkeypox symptoms and prevent serious outcomes, including death. NIAID and the DRC’s National Institute for Biomedical Research (INRB) are co-leading the trial as part of the government-to-government PALM partnership. Collaborating institutions include the U.S. Centers for Disease Control and Prevention (CDC), the Institute of Tropical Medicine Antwerp, the aid organization Alliance for International Medical Action (ALIMA) and the World Health Organization (WHO).

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Vanderbilt, NIH and the Institut National de Recherche Biomédicale Team Up to Tackle Monkeypox 

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Vanderbilt University
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Vanderbilt, NIH and the Institut National de Recherche Biomédicale Team Up to Tackle Monkeypox 
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U.S. Clinical Trial Evaluating Antiviral for Monkeypox Begins

A Phase 3 clinical trial evaluating the antiviral tecovirimat, also known as TPOXX, is now enrolling adults and children with monkeypox infection in the United States. Study investigators aim to enroll more than 500 people from clinical research sites nationwide. Interested volunteers can visit the ACTG website (clinical trial A5418) for more information. The NIAID-funded Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG) is leading the study, which may later expand to international sites. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at NIH is supporting several sites, including through the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT).

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Clinical Trial Evaluating Monkeypox Vaccine Begins

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers. The trial, which will enroll more than 200 adults across eight U.S. research sites, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. JYNNEOS is manufactured by Bavarian Nordic, based in Copenhagen. It is approved by the U.S.

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NIH Experts Review Monkeypox Challenges

Lessons learned from the public health responses to the HIV and COVID-19 pandemics should help guide the response to the current outbreak of monkeypox, National Institutes of Health experts write in an editorial published today in the New England Journal of Medicine. Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), and H.

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Veronique Nussenblatt, M.D, Sc.M., M.H.S

Education:

M.D., University of Maryland School of Medicine, Baltimore, MD

M.H.S, Johns Hopkins University, Baltimore, MD

Photo of Veronique Nussenblatt, M.D, Sc.M., M.H.S

Veronique Nussenblatt, M.D, Sc.M., M.H.S

Chief, Infectious Disease Consult Service
Associate Program Director, Infectious Disease Fellowship
Director, NIH Residency Electives Program (REP) and Clinical Electives Program (CEP) for Medical Students

Major Areas of Research

  • COVID-19

Biography

Dr. Nussenblatt received her M.D. from the University of Maryland School of Medicine and completed her internal medicine residency and infectious disease fellowship at the Johns Hopkins University School of Medicine. After completing her training, she joined the Infectious Disease faculty at The Johns Hopkins School of Medicine until she moved to Belgium where she spent two years providing clinical and scientific expertise for the development and implementation of clinical studies within two European clinical trial networks.

Program Description

Dr. Nussenblatt specialized in general infectious diseases as well as managing infections in immunocompromised hosts. She provides diagnostic and therapeutic expertise for the management of infections in patients enrolled in clinical protocols at the NIH. She has a particular interest in COVID-19 in immunocompromised patients. Dr. Nussenblatt provides clinical supervision and training of infectious disease fellows and of residents and medical students rotating on the Infectious Disease Consult Service at the NIH.  

Selected Publications

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Training Programs

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Infectious Disease Consult Service
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Veronique
Last Name
Nussenblatt
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Program Description

Dr. Nussenblatt specialized in general infectious diseases as well as managing infections in immunocompromised hosts. She provides diagnostic and therapeutic expertise for the management of infections in patients enrolled in clinical protocols at the NIH. She has a particular interest in COVID-19 in immunocompromised patients. Dr. Nussenblatt provides clinical supervision and training of infectious disease fellows and of residents and medical students rotating on the Infectious Disease Consult Service at the NIH. 

Selected Publications

Suh GA, Lodise TP, Tamma PD, Knisely JM, Alexander J, Aslam S, Barton KD, Bizzell E, Totten KMC, Campbell JL, Chan BK, Cunningham SA, Goodman KE, Greenwood-Quaintance KE, Harris AD, Hesse S, Maresso A, Nussenblatt V, Pride D, Rybak MJ, Sund Z, van Duin D, Van Tyne D, Patel R; Antibacterial Resistance Leadership Group. Considerations for the Use of Phage Therapy in Clinical Practice. Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0207121.

Nussenblatt V, Roder AE, Das S, de Wit E, Youn JH, Banakis S, Mushegian A, Mederos C, Wang W, Chung M, Pérez-Pérez L, Palmore T, Brudno JN, Kochenderfer JN, Ghedin E. Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion. medRxiv [Preprint]. 2021 Oct 5:2021.10.02.21264267.

Melendez-Munoz R, Marchalik R, Jerussi T, Dimitrova D, Nussenblatt V, Beri A, Rai K, Wilder JS, Barrett AJ, Battiwalla M, Childs RW, Fitzhugh CD, Fowler DH, Fry TJ, Gress RE, Hsieh MM, Ito S, Kang EM, Pavletic SZ, Shah NN, Tisdale JF, Gea-Banacloche J, Kanakry CG, Kanakry JA. Cytomegalovirus Infection Incidence and Risk Factors Across Diverse Hematopoietic Cell Transplantation Platforms Using a Standardized Monitoring and Treatment Approach: A Comprehensive Evaluation from a Single Institution. Biol Blood Marrow Transplant. 2019 Mar;25(3):577-586.

Sigfrid L, Reusken C, Eckerle I, Nussenblatt V, Lipworth S, Messina J, Kraemer M, Ergonul O, Papa A, Koopmans M, Horby P. Preparing clinicians for (re-)emerging arbovirus infectious diseases in Europe. Clin Microbiol Infect. 2018 Mar;24(3):229-239.

Nussenblatt V, Avdic E, Berenholtz S, Daugherty E, Hadhazy E, Lipsett PA, Maragakis LL, Perl TM, Speck K, Swoboda SM, Ziai W, Cosgrove SE. Ventilator-associated pneumonia: overdiagnosis and treatment are common in medical and surgical intensive care units. Infect Control Hosp Epidemiol. 2014 Mar;35(3):278-84.

Visit PubMed for a complete publication listing.

Additional Information

Training Programs

Major Areas of Research
  • COVID-19