Collaborations that uncovered the underlying genetic and cellular causes of specific immune disorders have, in some cases, resulted in novel treatments. Three such novel treatments are being actively investigated through a clinical treatment trial at NIH:
- Immunologic Effects of Supplemental Monosaccharide and Nucleoside Derivatives in Patients With Inherited Disorders of Glycosylation, 15-I-0159
- Study of Efficacy of CDZ173 in Patients With PASLI/APDS, NCT02435173
- Study of Magnesium Supplementation in Patients With XMEN Syndrome
- Phase 1/2 trial of amino acid supplementation in patients with atopic disease with or without a defect in the mTORC1 pathway