Systems Biology for Infectious Diseases Research

The Systems Biology for Infectious Diseases Research Programs develop and validate predictive models of infectious disease initiation, progression, and outcomes.

These models are derived from the study of the architecture and dynamics of systems-wide host/pathogen molecular interaction networks during infection, using integrated datasets generated from a combination of “omics” technologies. The research findings will provide a deeper understanding of the overall complexity of the biological, biochemical, and biophysical molecular processes within microbial organisms as well as their interaction with the host.

The programs provide data and reagents that result from the research conducted and provide training for the broader infectious disease scientific community to promote the use of the systems biology approach.

Where Services Are Provided?

General infectious disease systems biology research is carried out by

Systems biology studies work specific to antibacterial resistance is carried out by

  • Baylor College of Medicine (Contact PI: Tor Savidge)
  • Boston College (Contact PI: Tim van Opijnen)
  • Los Angeles Biomedical Institute at Harbor-UCLA Med (Contact PI: Michael Yeaman)
  • University of Michigan (Contact PI: Vincent Young)
  • University of California San Diego (Contact PI: Bernhard Palsson)
  • Sloan-Kettering Institute for Cancer Research (Contact PI: Eric Pamer)


Data and software generated by Centers is being made available through publicly accessible Web and database sites, including the NIAID Bioinformatics Resource Centers.

Reagents are being made available through the program participants listed above.

Training in systems biology and “omics” technologies may be provided by the Centers. Please contact individual Centers for information regarding training opportunities.

Information and Related Resources

Content last reviewed on November 10, 2016