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The Bioinformatics and Computational Biosciences Branch's (BCBB) structural biology team develops and applies theoretical and computational methods to biological problems at the molecular level. Our work encompasses a broad range of topics relevant to structural biology, from quantum chemical calculations of small molecules to large-scale simulations of macromolecules and their complexes. Specific topics include the physicochemical modeling of proteins and nucleic acids, mechanism-based design of drugs and image probes, the structure, dynamics, and kinetics of proteins, enzyme mechanisms, molecular recognition, protein-ligand association, and multiprotein complexation. We are also interested in the application of mathematical and statistical methods to data analysis and image reconstruction problems and the integration of molecular and machine learning approaches.

Last Reviewed: January 10, 2025

This document provides a progress report for NIAID Biodefense Research Agenda for Category B and C Priority Pathogens.

Last Reviewed: August 6, 2019

This document provides CRSs with guidance on the premature termination or suspension of a clinical trial.

Last Reviewed: October 2, 2023

The COVID-19: How SARS-CoV-2 binds to host cells module is part of the Pathogens in Augmented Reality (PathogenAR) mobile app. COVID-19 is a severe respiratory infection caused by the SARS-CoV-2 virus. In order to infect host cells, SARS-CoV-2 has a surface protein which can specifically bind to another surface protein on host cells. Disrupting this interaction is key to several vaccines and

Last Reviewed: February 3, 2021

Women who receive an mRNA-based COVID-19 vaccination or booster during pregnancy can provide their infants with strong protection against symptomatic COVID-19 infection for at least six months after birth. These findings reinforce the importance of receiving both a COVID-19 vaccine and booster during pregnancy to ensure that infants are born with robust protection that lasts until they are old enough to be vaccinated.

Published: February 14, 2024

This study is a prospective, multi-center, randomized, double blinded, placebo-controlled study of OCR treatment-discontinuation in patients with early RMS.

Targeting the Parasite within the Vector: Exploring Novel Approaches to Prevent Transmission of Vector-Borne Diseases

Last Reviewed: March 31, 2022

Sample application from Mohammad Ayoub Mir

Last Reviewed: August 4, 2017

Jordan Report: Accelerated Development of Vaccines (2012) from NIAID includes updates on vaccine research for specific infectious diseases.

Last Reviewed: December 31, 2012

The Papillomavirus: The HPV Minichromosome module is part of the Pathogens in Augmented Reality (PathogenAR) mobile app. Papillomaviruses replicate in cells of the skin, mouth and anogenital region of the human host. HPV infection can be asymptomatic, cause warts, or disrupt cell growth. On rare occasions, the cell growth becomes uncontrolled, causing cancer. About 5% of cancers worldwide are

Last Reviewed: May 9, 2024

An experimental approach to enhancing a standard cat allergen immunotherapy, often called allergy shots, made it more effective and faster acting, and the benefits persisted for a year after treatment ended.

Published: October 11, 2022

Food and Drug Administration announced the approval of the first respiratory syncytial virus (RSV) vaccine approved for use in the United States. The vaccine, Arexvy, is approved for the prevention of lower respiratory tract disease caused by RSV in individuals 60 years of age and older.

Published: May 4, 2023

7.5% of U.S. adults develop post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. PASC is characterized by varying symptoms, including fatigue, shortness of breath, heart palpitations or chest pain, brain fog, insomnia, dizziness, and joint or muscle pain.

Last Reviewed: July 7, 2023

Lead Institution: Mahidol University Research Areas The epidemiology of malaria in Southeast Asia (SEA) is dynamic and rapidly changing as a result of modifications to the environment and human factors. As SEA countries strive to eliminate malaria, they encounter unique challenges, including the transition from predominantly Plasmodium falciparum to increasing P. vivax infections and spatial

Last Reviewed: July 12, 2024

The NIAID Structural Genomics Centers for Infectious Diseases use state-of-the-art technologies to characterize the 3-D structure of proteins.

Last Reviewed: September 10, 2024

Expert articles from Jordan Report: Accelerated Development of Vaccines (2012) from NIAID

Last Reviewed: December 31, 2012

The mission of Neuroimmunological Disease Section is to understand, diagnose, prognosticate and cure neuroimmunological diseases.

Last Reviewed: February 19, 2025

A NIH study to determine the rate of novel coronavirus infection in children and family members in the United States has begun enrolling participants.

Published: May 4, 2020

The elevated cardiovascular disease risk among people with HIV is even greater than predicted by a standard risk calculator in several groups, including Black people and cisgender women, according to analyses from a large international clinical trial primarily funded by the National institutes of Health and presented at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in

Published: March 4, 2024

The Research Technologies Branch (RTB) Structural Biology Section (SBS) provides specialized techniques and scientific expertise that enables Division of Intramural Research (DIR) scientists to obtain biophysical and structural data for macromolecules. While closely collaborating with DIR researchers, the SBS provides consulting/training, produces pure proteins, performs biophysical analyses, and

Last Reviewed: July 26, 2022

A series of experiments with highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses circulating in infected U.S. dairy cattle found that viruses derived from lactating dairy cattle induced severe disease in mice and ferrets when administered via intranasal inoculation.

Published: July 8, 2024

This document outlines systematic evaluation of nine monogenic autoinflammatory diseases.

Last Reviewed: April 7, 2021

Biology of spirochetes Bacterial regulatory RNAs and proteins Bacterial transcriptomics Determinants of Borrelia burgdorferi tick and mammalian infection Molecular Genetics of Treponema pallidum

Last Reviewed: February 19, 2025

Information about Father of the NIH, Dr. Kinyoun, and his role in fighting the plague in San Francisco.

Last Reviewed: August 28, 2012

Davis-Gardner ME et al. Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster. NEJM, 2022 December Wang Q et al. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell, 2022 December Kurhade C et al. Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster. Nature Medicine, 2022

Last Reviewed: January 6, 2023