Chronic Granulomatous Disease Studies

Microscopic slide of neutrophils from the blood of a patient with CGD.

Neutrophils from the blood of a patient with CGD.

Credit: NIAID

Chronic granulomatous disease (CGD) is a genetic disorder in which white blood cells called phagocytes are unable to kill certain types of bacteria and fungi. People with CGD are highly susceptible to infections, such as Staphylococcus aureus, Serratia marcescens, Burkholderia cepaciaNocardia species, and Aspergillus species. NIAID aims to improve diagnosis, explore new treatments and preventions, and facilitate genetic counseling for this primary immune deficiency disease.

Current Clinical Research Studies Seeking Volunteers 

The following are selected NIAID-supported clinical research activities that are seeking participation by CGD patients. The links lead to full study descriptions, eligibility criteria and contact information. 

Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease (NCT01851460) 

This study evaluates the feasibility, safety, and to a lesser extent, efficacy of radiofrequency ablation to treat liver abscesses in subjects with previously diagnosed CGD. 

Patients Treated for Chronic Granulomatous Disease Since 1995 (NCT02082353) 

This study will determine the long-term medical condition and daily functioning of participants with CGD after a transplant and if possible, compare these results to participants who do not undergo a transplant. 

Use of G-CSF to Obtain Blood Cell Precursors (NCT00001405) 

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases. 

Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations (NCT03278912)

The objective of this study is to learn more about when and why inflammatory bowel syndrome may develop in some people with primary immunodeficiency diseases. 

Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease (NCT02234934) 
This study assesses the safety, feasibility and efficacy of cellular gene therapy in patients ages 23 months and older with chronic granulomatous disease using bone marrow transplant. 

Participation in a Research Registry for Immune Disorders (NCT01953016) 

The objective of this study is to collect data on people with primary immune deficiency disorders. 

Evaluation of Patients With Immune Function Abnormalities (NCT00128973) 

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation. 

Read more about NIAID’s research on Primary Immune Deficiency Diseases (PIDDs)

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