Pvs230D1-EPA/MM Phase 1 Study

Researchers at the Laboratory of Malaria Immunology and Vaccinology seek healthy volunteers to participate in a malaria vaccine research study. This study aims to develop a new and safe vaccine that will help stop the spread of malaria.

What Does the Study Involve?

If you are interested in this study, you will first have a phone call with our research team to learn more about the study. You will also complete a series of yes and no questions about your health to see if you may qualify. Next, you will come to the clinic for an in-person screening visit to further see if you are eligible to participate in the study. At this visit, you will have a physical exam and have blood and urine samples collected. 

If you qualify and decide to join the study, you will be given a new, investigational malaria vaccine. You will receive 3 doses of this vaccine. You will be given each dose about one month apart. You will also have multiple follow-up clinic visits, and we will check in by phone to ensure you are doing well and in good health. In total, we will ask you to complete 7 phone calls and come to our clinic 16 times. We will be taking a small amount of blood for lab tests at most of these clinic visits.

This study will take place at the NIH Clinical Center. You will be in the study for about 16 months. 

Who Can Participate?

Healthy adults: 

  • 18 - 50 years old
  • Living in the Washington, DC metropolitan area

Where Is It Taking Place?

5SW Day Hospital at the NIH Clinical Center

Is There a Cost?

No

Is Compensation Provided

Yes

Number of Visits

You will have 16 clinic visits and 7 follow-up phone calls:

  • 1 screening visit 
  • 3 vaccination visits
  • 12 follow-up clinic visits
  • 7 follow-up phone calls

Steps to Participate

Contact the LMIV Clinical Team 

Email: LMIVClinicalTrial@mail.nih.gov

Phone: 240-292-4999

Visit ClinicalTrials.gov for details

Visit ClinicalTrials.gov for details.

Contact Information

Contact the LMIV Clinical Team

Email: LMIVClinicalTrial@mail.nih.gov

Phone: 240-627-3355 
 

Participating in Research

Watch a series of short informational videos about participating in clinical trials. These videos are intended to help potential participants understand how research works, what questions they should consider asking, and things to think about when deciding whether or not to participate in a study.

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