Using an integrated approach that combines basic, translational, and clinical research on asthma and allergic diseases, AADCRC investigators have made the following scientific advances:
- Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations. Zhong X, et al. Genome Med. (2025)
- Peanut Oral Immunotherapy in Children with High-Threshold Peanut Allergy. Sicherer SH, et al. NEJM Evid. (2025)
- A Phenotypically Distinct Human Th2 Cell Subpopulation Is Associated With Development of Allergic Disorders in Infancy. Pizzarello CR, et al. Allergy. (2025)
- Early-life upper airway microbiota are associated with decreased lower respiratory tract infections. Zelasko S, et al. J Allergy Clin Immunol. (2025)
- Progressive accumulation of hyperinflammatory NKG2Dlow NK cells in early childhood severe atopic dermatitis. Ochayon DE, et al. Sci Immunol. (2024)
- Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2. Alhallak K, et al. Immunity. (2024)
- Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma. Murphy RC, et al. Am J Respir Crit Care Med. (2023)
- Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study. Rosas-Salazar C, et al. Lancet. (2023)
- Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. Miki H, et al. J Allergy Clin Immunol. (2023)
- CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy. Kaushik A, et al. Nat Commun. (2022)
- Epithelial miR-141 regulates IL-13-induced airway mucus production. Siddiqui S, et al. JCI Insight. (2021)
- Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma. Francisco D, et al. J Immunol. (2020)