The AADCRC program is the cornerstone of NIAID efforts to promote multidisciplinary basic and clinical research on the immunological basis, pathobiology, diagnosis, treatment, and prevention of asthma and allergic diseases.
Main Areas of Focus
- Investigate the immune system’s role in the development, treatment, and prevention of asthma and allergic diseases
- Determine how immune responses to viral and microbial infection may contribute to the development or worsening of asthma and allergic diseases
- Determine how the microbiomes of the environment and those within various parts of the body may play a preventive role or contribute to the development or worsening of asthma and allergic diseases
- Understand the role of pollution and environmental exposures in the development, persistence, and worsening of asthma
- Investigate the role of epithelial-immune and/or neuroimmune interactions in the development, persistence, and severity of allergic diseases
- Assess mechanisms of allergen immunotherapy-induced clinical desensitization and tolerance for the treatment of asthma and allergic diseases, and improve the efficacy, safety, and ease of use of this therapeutic modality
- Investigate genetic variations and epigenetic alterations affecting host immune responses to allergens, and patient responses to therapeutic interventions in asthma and allergic diseases
- Translate discoveries into medical practice, with a focus on immune-based therapies and preventive approaches for asthma and allergic diseases
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