AADCRC investigators conduct clinical research studies on asthma and allergic diseases, as well as respiratory infections, to explore:
- Multi-omic approaches to post-GWAS discovery in asthma
- Combination biologics and immunotherapy to treat multi-food allergy
- Viral, host, and environmental determinants of respiratory viral illness severity and of infant/childhood allergy and asthma pathogenesis
- The role of the epithelium and mucosal and innate immunity in allergic inflammation and asthma
- Therapy and mechanisms in aspirin-exacerbated respiratory disease, a severe form of nasal polyposis and asthma
- Mechanisms of atopic dermatitis and progression of atopic diseases
- The immune basis and clinical implications of threshold-based phenotypes in peanut allergy
The AADCRC program is conducting or has recently completed the following clinical trials and observational studies (see ClinicalTrials.gov for more information on individual clinical trials; observational studies are not included in ClinicalTrials.gov):
- Immune Basis and Clinical Implications of Threshold-based Phenotypes of Peanut Allergy (CAFETERIA): NCT03907397
- Clinical Study Using Biologics to Improve Multi OIT Outcomes (COMBINE): NCT03679676
- Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease (MARINER): NCT05575037
- Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure (INSPIRE) Observational Study
- Childhood Allergy and the NeOnatal Environment Ancillary Study of the Impact of Respiratory Viral Illness on the Airway Epithelium and Microbiome (CANOE-VU)
- Wisconsin Infant Study Cohort with Traditional Agrarian Families (WISC+) and Microbial Associated Respiratory Illnesses (MARI)
- Mechanisms of Progression of Atopic Dermatitis to Asthma in Children (MPAACH)
- Zooming Into Old Order Mennonites (ZOOM)
Participating AADCRC Sites
- Brigham & Women's Hospital, Boston, MA—Joshua Boyce, M.D.
- Cincinnati Children's Hospital Medical Center, Cincinnati, OH—Gurjit Hershey, M.D., Ph.D.
- Stanford University, Palo Alto, CA—Stephen Galli, M.D.
- University of Arizona, Tucson, AZ—Monica Kraft, M.D.
- University of California, San Diego, CA—David Broide, M.D., Ch.B.
- University of California, San Francisco, CA—David Erle, M.D.
- University Of Chicago, Chicago, IL—Carole Ober, Ph.D.
- University of Rochester, Rochester, NY—Kirsi Jarvinnen-Seppo, M.D., Ph.D.
- University of Washington, Seattle, WA—Teal Hallstrand, M.D.
- University of Wisconsin, Madison, WI—James Gern, M.D.
- Vanderbilt University, Nashville, TN—Tina Hartert, M.D.