Using an integrated approach that combines basic, translational, and clinical research on asthma and allergic diseases, AADCRC investigators have made the following scientific advances:
- Increased H1N1 infection in children with asthma. Kloepfer KM et al., Am J Respir Crit Care Med. 185(12):1275-9 (2012)
- Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life. Sumino K et al., J Allergy Clin Immunol. 129(5):1267-73 (2012)
- Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilic and lymphocytic inflammation. Medina JL et al., Am J Respir Cell Mol Biol. 46(6):815-22 (2012)
- Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers. Hernandez ML et al., J Allergy Clin Immunol. 130(4):869-76 (2012)
- The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Schneider M et al., Nat Immunol. 13(9):823-31 (2012)
- Differences in candidate gene association between European ancestry and African American asthmatic children. Baye TM et al., PLoS One. 6(2):e16522. doi: 10.1371/journal.pone.0016522 (2011)
- Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Rothenberg ME et al.., Nat Genet. 42(4):289-91 (2010)
- Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge. Eckman JA et al., J Allergy Clin Immunol. 125(4):889-895.e7 (2010)