NIH Center for Human Immunology, Inflammation, and Autoimmunity Publications

FY 2022 Publications

Peroxisome proliferator activated receptor-γ agonist pioglitazone improvesvascular and metabolic dysfunction in systemic lupus erythematosus.
Hasni S, Temesgen-Oyelakin Y, Davis M, Chu J, Poncio E, Naqi M, Gupta S, Wang X, Oliveira C,Claybaugh D, Dey A, Lu S, Carlucci P, Purmalek M, Manna ZG, Shi Y, Ochoa-Navas I, Chen J,Mukherjee A, Han KL, Cheung F, Koroleva G, Belkaid Y, Tsang JS, Apps R, et al. [7 more authors] (2022) Ann Rheum Dis, in press(e-pub ahead of print).

HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype.
Li SS, Hickey A, Shangguan S, Ehrenberg PK, Geretz A, Butler L, Kundu G, Apps R, Creegan M,Clifford RJ, Pinyakorn S, Eller LA, Luechai P, Gilbert PB, Holtz TH, Chitwarakorn A, Sacdalan C,Kroon E, Phanuphak N, de Souza M, Ananworanich J, O'Connell RJ, Robb ML, Michael NL, VasanS, et al. [1 more author] (2022). Cell Host Microbe 30, 1173-1185.e8.

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.
Sacco K, Castagnoli R, Vakkilainen S, Liu C, Delmonte OM, Oguz C, Kaplan IM, Alehashemi S,Burbelo PD, Bhuyan F, de Jesus AA, Dobbs K, Rosen LB, Cheng A, Shaw E, Vakkilainen MS, PalaF, Lack J, Zhang Y, Fink DL, Oikonomou V, Snow AL, Dalgard CL, Chen J, Sellers BA, NIAIDImmune Response to COVID Group, Chile MIS-C Group, Pavia Pediatric COVID-19 Group, et al.[37 more authors] (2022). Nat Med 28, 1050-1062.

FY 2021 Publications

Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness.
Han K, Singh K, Rodman MJ,et al. Nutrients. 2021 Apr 28;13(5):1492. doi: 10.3390/nu13051492. PMID: 33924911.

Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics.
Kotliar D, Lin AE, Logue J, et al. Cell. 2020 Nov 25;183(5):1383-1401.e19. doi: 10.1016/j.cell.2020.10.002. Epub 2020 Nov 6. PMID: 33159858; PMCID: PMC7707107.

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Liu C, Martins AJ, Lau WW, et al. Cell. 2021 Feb 10:S0092-8674(21)00168-9. doi: 10.1016/j.cell.2021.02.018. Epub ahead of print. PMID: 33713619; PMCID: PMC7874909.

The complement pathway is activated in people with HIV and is associated with non-AIDS comorbidities.
Vujkovic-Cvijin I, Sortino O, Verheij E, et al.  J Infect Dis. 2021 Feb 19:jiab096. doi: 10.1093/infdis/jiab096. Epub ahead of print. PMID: 33606018.

Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease.
Ozen A, Kasap N, Vujkovic-Cvijin I, et al. Nat Immunol. 2021 Feb;22(2):128-139. doi: 10.1038/s41590-020-00830-z. Epub 2021 Jan 4. PMID: 33398182; PMCID: PMC7856263.

Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness.
Han K, Singh K, Rodman MJ, et alNat Metab. 2021 Mar 15. doi: 10.1038/s42255-021-00356-0. Epub ahead of print. PMID: 33723462. 

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Anjali Ramaswamy, Nina N. Brodsky, Tomokazu S. Sumida, et al. Immunity. 2021 Apr 13. doi: 10.1016/j.immuni.2021.04.003. Online ahead of print. PMID: 33891889

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.
Hasni SA, Gupta S, Davis M, et al. Nat Commun. 2021 Jun 7;12(1):3391. doi: 10.1038/s41467-021-23361-z. PubMed PMID: 34099646 

HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases. 
Vujkovic-Cvijin I, Sortino O, Verheij E, et al. Nat Commun 11, 2448. https://doi.org/10.1038/s41467-020-16222-8 

Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. 
Lima-Junior DS, Krishnamurthy SR, Bouladoux N,et al.  Cell. 2021 Jul 8;184(14):3794-3811.e19. doi: 10.1016/j.cell.2021.05.020. Epub 2021 Jun 23. PMID: 34166614; PMCID: PMC8381240. 

Immunopathological signatures in multisystem inflammatorysyndrome in children and pediatric COVID-19.
Sacco K, Castagnoli R, Vakkilainen S, Liu C, Delmonte OM, Oguz C, Kaplan IM, Alehashemi S,Burbelo PD, Bhuyan F, de Jesus AA, Dobbs K, Rosen LB, Cheng A, Shaw E, Vakkilainen MS, PalaF, Lack J, Zhang Y, Fink DL, Oikonomou V, Snow AL, Dalgard CL, Chen J, Sellers BA, NIAID Immune Response to COVID Group, Chile MIS-C Group, Pavia Pediatric COVID-19 Group, et al.[37 more authors] (2022). Nat Med 28, 1050-1062.

FY 2020 Publications

Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy. Apps R, Kotliarov Y, Cheung F, Han KL, Chen J, Biancotto A, Babyak A, Zhou H, Shi R, Barnhart L,Osgood SM, Belkaid Y, Holland SM, Tsang JS, Zerbe CS (2020). JCI Insight 5. https://doi.org/10.1172/jci.insight.134838

Colchicine’s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial.
Demidowich, A.P., Levine, J.A., Apps, R. et al. Int J Obes 44, 1793–1799 (2020).

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2.
Hopfensperger K, Richard J, Stürzel CM, Bibollet-Ruche F, Apps R, Leoz M, Plantier JC, Hahn BH, Finzi A, Kirchhoff F, Sauter D (2020). mBio 11.

Effects of rosuvastatin on the immune system in healthy volunteers with normal serum cholesterol.
Karmaus PW, Shi M, Perl S, Biancotto A, Candia J, Cheung F, Kotliarov Y, Young N, Fessler MB, CHI Consortium (2019). JCI Insight 4.

Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus.
Kotliarov Y, Sparks R, Martins AJ, Mulè MP, Lu Y, Goswami M, Kardava L, Banchereau R, Pascual V, Biancotto A, Chen J, Schwartzberg PL, Bansal N, Liu CC, Cheung F, Moir S, Tsang JS (2020). Nat Med 26, 618-629.

Cancer prognosis with shallow tumor RNA sequencing.
Milanez-Almeida P, Martins AJ, Germain RN, Tsang JS (2020).Nat Med 26, 188-192.

Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health.
Pasetti MF, Ackerman ME, Hoen AG, Alter G, Tsang JS, Marchant A (2020). Vaccine 38, 4491-4494.

Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease.
Ravell JC, Matsuda-Lennikov M, Chauvin SD, Zou J, Biancalana M, Deeb SJ, Price S, Su HC, Notarangelo G, Jiang P, Morawski A, Kanellopoulou C, Binder K, Mukherjee R, Anibal JT, Sellers B, Zheng L, He T, George AB, Pittaluga S, Powers A, Kleiner DE, Kapuria D, Ghany M, Hunsberger S, et al. [29 more authors] (2019). J Clin Invest 130, 507-522.

Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
Tsang JS, Dobaño C, VanDamme P, Moncunill G, Marchant A, Othman RB, Sadarangani M, Koff WC, Kollmann TR (2020). Trends Immunol 41, 457-465.

HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases.
Vujkovic-Cvijin I, Sortino O, Verheij E, Sklar J, Wit FW, Kootstra NA, Sellers B, Brenchley JM, Ananworanich J, Loeff MSV, Belkaid Y, Reiss P, Sereti I (2020). Nat Commun 11, 2448.

Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency.
Wu Z, Gao S, Diamond C, Kajigaya S, Chen J, Shi R, Palmer C, Hsu AP, Calvo KR, Hickstein DD, Holland SM, Young NS (2020). Blood Adv 4, 2656-2670.

Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia.
Çelik H, Lindblad KE, Popescu B, Gui G, Goswami M, Valdez J, DeStefano C, Lai C, Thompson J, Ghannam JY, Fantoni G, Biancotto A, Candia J, Cheung F, Sukumar G, Dalgard CL, Smith RH, Larochelle A, Dillon LW, Hourigan CS (2020). Blood Adv 4, 367-379.

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