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The aerobiology team develops aerosol animal models of disease caused by high-consequence pathogens. Using advanced inhalational technologies, this team provides high experimental reproducibility to ensure the best modeling possible. Aerosolization procedures are fine-tuned to achieve accurate and precise dosimetry.
Developing, characterizing, and refining animal models rely on sophisticated medical imaging equipment; aerosol capabilities; and virology, pathology, molecular biology, and immunology expertise.
The NIAID-funded Bioinformatics Resource Centers provide data-driven, production-level, sustainable computational platforms to enable sharing and access to data, portable computational tools, and standards that support interoperability for the infectious diseases research community.
The Clinical Studies Support Team (CSST) develops and fosters overseas relationships through continuous support of research studies and clinical trials involving pathogens of high consequence. When deployed, the team provides in-person training and assistance with assays, equipment, and project management.
The core services team provides cell culture, hematology, hemostasis, clinical chemistry, microbiology, and molecular virology support for infectious disease studies at the IRF-Frederick. The team has the ability to perform pre-screening assessment by having parallel setups of clinical analyzers in biosafety level 4 (BSL-4) and BSL-2.
The drug screening team tests and characterizes novel compounds, drugs, and antibodies against numerous viruses in multiple cell lines under a variety of conditions. Compounds are evaluated in cell-based assays for inhibition of viral replication and reduction of virus yields, plaques, or cytopathic effect.
The Early Phase Clinical Trial Units (EPCTUs) support the design, development, implementation, and conduct of Phase 0 to Phase 2 clinical trials, including proof-of-concept studies in healthy, special, and disease-specific populations, carried out in an expeditious and efficient manner, aided by bioanalysis when necessary, against viral, bacterial, parasitic, and fungal pathogens and
The electron microscopy (EM) laboratory team uses transmission electron microscopy (TEM), scanning electron microscopy (SEM), negative staining techniques and assays, immunogold labeling, quantitation of biological samples, and other specialized methods.
The pathology and histology teams work together to conduct morphologic assessments and molecular assays using in-life and postmortem samples attained during research studies that develop and use established animal models of high-consequence emerging human viruses.