Project Title: Analysis of SARS-CoV-2-specific antibody responses
NIAID Principal Investigator: Jeffrey Cohen M.D.
Chief, Laboratory of Infectious Diseases
Chief, Medical Virology Section, LID
What is the antibody profile during COVID-19 infection?
One of the key responses of the adaptive immune system to infection is the production of pathogen-specific antibodies by B cells. The Medical Virology Section, working with Dr. Peter Burbelo (NIDCR), is interested in performing serologic studies to better understand the epidemiology of COVID-19 in specific cohorts. The labs will look for autoantibodies against cellular proteins, such as those that have been reported in people with severe lung disease, which may help to uncover prognostic markers and provide insight into the efficacy of different experimental COVID-19 treatments. In addition to looking at COVID-19 spike and nucleocapsid binding antibodies, the lab is looking at spike antibodies that mediate ADCC and ADCP activity.
Serum or plasma (100 µL) is required. Longitudinal sampling in patients is highly desired, as well as specific patient cohorts to answer important epidemiologic questions.
The Medical Virology Section has a number of small aliquots of plasma samples from people known to be positive for COVID-19.