Major Areas of Research
- Plasmodium genetics and genomics
- Host-parasite interaction and molecular signaling
- Antimalarial drug development and mechanisms of drug resistance
Our laboratory develops and uses genetic and genomic approaches to study host-malaria parasite interaction and molecular mechanisms of the interaction using the rodent malaria parasite Plasmodium yoelii as a model. We have characterized large numbers of microsatellites and single nucleotide polymorphisms (SNPs) from several P. yoelii parasites and performed various genetic crosses to identify parasite genes linked to parasite development, virulence, and drug resistance. We are studying host immune signaling pathways in response to parasite infections, focusing on innate signaling and regulation of type I interferon production and inflammatory responses after malaria infection.
We are also interested in screening and development of new antimalarial drugs, particularly compounds that can block malaria transmission.
Dr. Su received his Ph.D. in parasitology from the University of Georgia in 1990. He joined the NIAID Laboratory of Parasitic Diseases in 1992 and became an investigator in the Laboratory of Malaria and Vector Research in 2001 and a senior investigator in 2006.
Xia L, Wu J, Pattaradilokrat S, Tumas K, He X, Peng YC, Huang R, Myers TG, Long CA, Wang R, Su X-z. Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention. Sci Rep. 2018 Oct 16;8(1):15280.
Sethu C. Nair, Ruixue Xu, Sittiporn Pattaradilokrat, Jian Wu, Yanwei Qi, Martine Zilversmit, Sundar Ganesan, Vijayaraj Nagarajan, Richard T. Eastman, Marlene S. Orandle, John C. Tan, Timothy G. Myers, Shengfa Liu, Carole A. Long, Jian Li and Su X-z. A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence. Nat Commun. 2017 Aug 9;8(1):223.
Yao X, Wu J, Lin M, Sun W, He X, Gowda C, Bolland S, Long CA, Wang RF, Su X-z. Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model. PLoS Pathog. 2016 Oct 7;12(10):e1005930.
Wu J, Cai B, Sun W, Huang R, Liu X, Lin M, Pattaradilokrat S, Martin S, Qi Y, Nair SC, Bolland S, Cohen JI, Austin CP, Long CA, Myers TG, Wang RF, Su XZ. Genome-wide analysis of host-Plasmodium yoelii interactions reveals regulators of the type I interferon response (link is external). Cell Rep. 2015 Jul 15;12:661-72.
Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets (link is external). Science. 2011;333(6043):724-9.