TrialNet Pathway to Prevention of Type 1 Diabetes

The goal of this study is to enhance understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes.

Contact Information

TrialNet Central Information Center
1-800-425-8361

Selected Clinical Trials About HIV/AIDS

NIAID is committed to conducting the research necessary to confront HIV/AIDS. Volunteer participation in a clinical research study helps NIAID better understand HIV, find promising new tools to prevent HIV infection including a vaccine, and develop new and more effective treatment strategies.

TRITON Study

We are studying a condition called paradoxical reaction that some people get when they take treatment for tuberculosis (TB). Most people with TB feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This opposite effect is a paradoxical reaction. We do not understand how this reaction happens. It can be hard to tell whether worsening symptoms are caused by a paradoxical reaction or something else, such as if the treatment just is not working.

Contact Information

Volunteer or get more information
Toll free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Emailprpl@mail.cc.nih.gov

EPIC Study

The primary objective of this NIAID study is to further characterize the natural history of idiopathic CD4 lymphocytopenia (ICL).

Contact Information

Volunteer or get more information
Toll free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Emailprpl@mail.cc.nih.gov

WINGS Healthy Volunteer Study

The purpose of the study is to test HIV vaccines to see if they are safe. It is not possible to get HIV through participating in the study. Vaccines are used to create resistance to a disease, or to prevent infection. The study vaccines will use a live adenovirus, the type of virus that typically causes cold symptoms. We hope that this adenovirus will help to stimulate an immune response against HIV.

Contact Information

Volunteer or get more information
Toll free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Emailprpl@mail.cc.nih.gov

RPHI Study

Our laboratory is recruiting people living with HIV to further understand the mechanism(s) involved in maintenance of immune function following early intervention with antiretroviral therapy. In addition, for purposes of comparison, patients who have passed the early stage of HIV are also being recruited.

Contact Information

Volunteer or get more information
Toll free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Emailprpl@mail.cc.nih.gov

PANDORA Study

This study will look for the development of IRIS (Immune Reconstitution Inflammatory Syndrome), a condition that can happen in patients diagnosed with HIV, after they begin treatment with antiretroviral therapy (ART).

Contact Information

Volunteer or get more information
Toll free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Emailprpl@mail.cc.nih.gov

A Participant’s Guide to Clinical Trials

Select a Language: EnglishEspañolFrançais

What Are Clinical Trials?

Clinical trials are research studies in which people help doctors find ways to improve health. Each study seeks to answer scientific questions and to find better ways to prevent, diagnose, or treat disease. Medical products, such as drugs, vaccines, and diagnostic tests, have to be studied in clinical trials before they can be approved for public use. 

A clinical trial follows a plan or “protocol” that is reviewed and approved before the trial can begin. This review ensures, among other things, that the trial follows appropriate safety guidelines.

What Happens in a Clinical Trial?

If you are interested in volunteering for a clinical trial, first find out if you are right for that trial and if the trial is right for you. Each trial has rules about who can volunteer. For example, you may have to weigh a certain amount, have certain blood tests, or be taking or not taking certain drugs. Depending on the needs of the trial, researchers may seek volunteers who are healthy or who are receiving care for a medical condition. Talk to your doctor to see if a clinical trial is right for you.

If you fit the rules of the trial, all details, including risks, benefits, and requirements of participating in the trial, will be explained to you. You will then be asked to sign an informed consent form, which shows that you understand what the trial entails and that you are willing to participate.

Will You Still See Your Regular Doctor?

Yes, you will still be under the care of your regular doctor for your general health. You will see the study doctor or nurse for planned study visits.

Do You Have To Pay Anything?

There is no charge for study-related medical care, including study visits, medications, treatments, and procedures. Transportation and other costs may be provided.

How Long Is a Clinical Trial?

The length of each trial is different. Some last a few months, others last for several years. You are free to leave the trial at any time.

What Is NIAID?

The National Institute of Allergy and Infectious Diseases (NIAID) conducts and supports research to better understand, treat, and prevent infectious, immunologic, and allergic diseases. NIAID research has improved the health of millions of people in the United States and around the world. NIAID is part of the National Institutes of Health.

Contact Information

Call:

Toll-free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español

Write:

Patient Recruitment
National Institutes of Health Clinical Center, NIH
Bethesda, MD 20892-2655

Clinical Trials at NIAID

NIAID conducts many clinical trials at the NIH Clinical Center, America’s research hospital, which is located on the main campus in Bethesda, Maryland. Read more about the NIH Clinical Center and its mission.

Search for a Clinical Trial

Healthy Volunteers: Healthy volunteers are people with no known significant health problems. See a list of all trials that are seeking healthy volunteers.

More Trials: Not all NIAID clinical trials are listed here. You may find more trials at ClinicalTrials.gov

NIAID conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. For more than 60 years, NIAID research has led to new therapies, vaccines, diagnostic tests, and other technologies that have improved the health of millions of people in the United States and around the world.

NIAID Clinics

HIV and Emerging Infectious Diseases

Information about NIAID-supported research on HIV and emerging infectious diseases including featured clinical trials.

Laboratory of Infectious Diseases

Background information about the NIAID Laboratory of Infectious Diseases (LID) including featured trials.

NIAID Primary Immune Deficiency Clinic

The NIAID Primary Immune Deficiency (PID) Clinic is dedicated to researching the 200+ forms of primary immune deficiency diseases.

Vaccine Research Center Clinical Studies

An overview of featured clinical studies at the NIAID Vaccine Research Center and information for potential volunteers.

What is it Like to Participate?

Photo of  Peter Hubbard

Based on my personal experiences, I encourage people to look into the clinical trials at the VRC. You really cannot ask for nicer or more dedicated and knowledgeable staff than those at the VRC, and they appreciate all of their volunteers. Give it a shot and be a part of something truly important!

– Peter Hubbard

Information For Researchers

Access Clinical Trials Data

NIAID Clinical Trials Data Repository, AccessClinicalData@NIAID, is an NIAID cloud-based, secure data platform that enables sharing of and access to anonymized individual, patient level clinical data sets from NIAID sponsored clinical trials to harness the power of data to generate new knowledge to understand, treat, and prevent infectious diseases such as COVID-19.

Explore all NIAID clinical resources for researchers

Fungal Disease Studies

Fungi are everywhere. Most fungi are not dangerous, but some types can be harmful to health, and people with deficient immune systems are more vulnerable to symptomatic infection. NIAID researchers are exploring how fungal susceptibility and infection impact the function of immune cells.