Miller School, CUNY Collaborate on $3.9 Million Study on HIV Risk and Meth Use in Gay Men

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://physician-news.umiamihealth.org/miller-school-cuny-collaborate-on-3-9-million-study-on-hiv-risk-and-meth-use-in-gay-men/
Research Institution
University of Miami Miller School of Medicine
Short Title
Miller School, CUNY Collaborate on $3.9 Million Study on HIV Risk and Meth Use in Gay Men
Content Coordinator
Claudia Wair
Content Manager
Kathy Donbeck

Smartwatches and fitness bands reveal individual physiological responses to COVID-19 vaccine

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.scripps.edu/news-and-events/press-room/2022/20220419-quer-covid19-vaccine.html
Research Institution
Scripps Research
Short Title
Smartwatches and fitness bands reveal individual physiological responses to COVID-19 vaccine
Content Coordinator
Claudia Wair
Content Manager
Kathy Donbeck

ACTG Launches A5383, Clinical Trial Evaluating Potential Immunologic Benefits Of Treating Asymptomatic CMV In People Living With HIV

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://actgnetwork.org/2022/04/22/actg-launches-a5383-clinical-trial-evaluating-potential-immunologic-benefits-of-treating-asymptomatic-cmv-in-people-living-with-hiv/
Research Institution
ACTG
Short Title
ACTG Launches A5383, Clinical Trial Evaluating Potential Immunologic Benefits Of Treating Asymptomatic CMV People Living With HIV
Content Coordinator
Claudia Wair
Content Manager
Kathy Donbeck

Behavioral and Social Sciences

Journal Special Supplement

The NIAID-NIMH BSSPT is collaborating with the Journal of the International AIDS Society to publish a special issue on “Advancing Use of Long-Acting and Extended Delivery (LAED) HIV Prevention and Treatment Regimens,” to be published in July 2023.  This special supplement will contain a set of multidisciplinary research articles designed to advance the development, future use, and equitable delivery of long-acting and extended delivery (LAED) regimens for HIV prevention and treatment. Guest editors of the special issue include Charles W. Flexner, Johns Hopkins University, United States; Jose A. Bauermeister, University of Pennsylvania, United States; and Sinead Delany-Moretlwe, University of the Witwatersrand, South Africa.

Main Areas of Focus

  • Enhance the integration of behavioral and social sciences in HIV biomedical clinical research using multiple communication tools including an informational website, brochures, meetings, webinars, and publications;
  • Strengthen the impact of behavioral and social sciences in HIV biomedical clinical research by engaging behavioral and social sciences researchers, clinicians and other stakeholders and facilitating connections among these groups;
  • Improve knowledge of BSS research methods, approaches and findings through collaboration with stakeholders.

BSSPT Membership

The BSSPT membership includes program staff from NIAID Office of the Director, Vaccine Research Program, Prevention Sciences Program, Therapeutic Research Program, and the National Institute of Mental Health (NIMH) Division of AIDS Research (DAR).

Contact Information

For more information or questions, please email the NIAID NIMH BSSPT at niaidnimhbsspt@mail.nih.gov.

Content Coordinator
Terry Senn
Content Manager
Terry Senn
Banner (Hero) Image
Behavioral Social Sciences, hero, multicolored faces, iStock
Introduction

The mission of the Behavioral and Social Sciences Project Team (BSSPT) is to enhance the integration of behavioral and social sciences (BSS) into biomedical HIV clinical research, including clinical trials of HIV vaccines, non-vaccine prevention, therapeutics, and cure research, to better address the HIV epidemic.

Behavioral and social sciences have contributed to our understanding of HIV prevention and treatment since the beginning of the epidemic. BSS has been successfully integrated into HIV clinical trials by developing multidisciplinary research teams and including behavioral and social scientists on research concept and protocol teams from the earliest stages of study development.

Networks & Programs
Behavioral Social Sciences

NIH Targeted Delivery Interest Group (TDIG) Webinars

NIH Targeted Delivery Interest Group (TDIG)

TDIG Monthly Webinar

The TDIG monthly webinar series will facilitate ideas exchanges and collaborations among academia, pharma, government, and the regulatory communities.

See the webinar schedule and information about past webinars.

TDIG Monthly Webinar Series is open to all.

Contact Information

Content Coordinator
Roger Ptak
Krista Townsend
Content Manager
Joy Liu
Introduction

The Targeted Delivery Interest Group (TDIG) is a NIH multi-institutional team that champions targeted delivery of therapeutics to different organs for selective and effective treatments with reduced harmful effects. The group aims to identify gaps and opportunities to advance basic, translational, and clinical research for multiple delivery platforms applicable for the treatment of multiple diseases including autoimmunity, transplantation, cancers, neurodegeneration, cardiovascular diseases, and infectious diseases.

Networks & Programs
Targeted Delivery Interest Group
No local navigation
Off

Notice of Special Interest (NOSI)—Towards Developing a Cure for HBV in HIV/HBV Co-Infection

Notice of Special Interest (NOSI)— Sustained Release of Antivirals for Treatment or Prevention of HIV or Treatment of Latent TB/HBV (SRATP)

The purpose of this Notice is to encourage new applications to support further development of a diverse and comprehensive portfolio of SR/LA products for prevention and treatment of HIV. SR/LA antiretroviral products will have a minimum window of protection of three (3) months from either a single dosing (injection, oral administration) or continuous dosing regimen (implant, transdermal patch, etc.) to reflect current state of SR/LA drug market for HIV treatment or prevention.

Pedro H. Gazzinelli Guimaraes, Ph.D.

Staff Scientist, Helminth Immunology Section
Pedro H. Gazzinelli Guimaraes headshot
Pedro H. Gazzinelli Guimaraes
Credit
NIAID

Major Areas of Research

  • Interaction between allergen- and helminth-driven type-2 immune responses
  • Biomarkers for helminth antigens- and allergens-specific human Th2 cells subsets
  • Multiomic profiling and TCR repertoire diversity of effector Th2 cells in the context of allergic diseases and helminth infections in both human studies and experimental models
  • Mechanisms of type-2 immune response induced by helminth infection and allergic sensitization in the lung tissue of experimental models
  • Influence of helminth infections on the regulation of the immune response of allergic individuals

Program Description

Dr. Gazzinelli-Guimaraes’ research program has been focused on the regulation of the immune response to helminth parasitic infections and to the pathogenesis of allergic diseases. 
We have a  specific interest in understanding the plasticity and specificity of circulating peripheral and tissue-resident effector Th2 cells driven by helminth antigens and/or allergens, as well as to understand the role of the effector Th2 subsets in the establishment of tissue Type-2-mediated inflammation using both mouse models and human studies. These studies aim to identify potential targets for the development of selective immunotherapy that could prevent chronic helminth infection or that could diminish allergic inflammation.

Biography

Dr. Gazzinelli Guimaraes received his master’s degree in Parasitology in 2010 from the Federal University of Minas Gerais, Brazil, and received his Ph.D. in 2014 from the same university. This was followed by a consulting training at the Schistosomiasis Control Initiative (SCI) based at Imperial College - London, UK in 2015, where he then became the supervisor of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) project in Cabo Delgado, Mozambique, managed by the University of Georgia–USA. He joined NIH in 2016 as a post-doctoral research fellow with Dr. Thomas Nutman in the Laboratory of Parasitic Diseases (LPD), NIAID. He is currently a Staff Scientist in LPD.

Publications

Kupritz J, Angelova A, Nutman TB, Gazzinelli-Guimaraes PH. Helminth-Induced Human Gastrointestinal Dysbiosis: a Systematic Review and Meta-Analysis Reveals Insights into Altered Taxon Diversity and Microbial Gradient Collapse. mBio. 2021 Dec 21;12(6):e0289021.

Gazzinelli-Guimaraes PH, Bennuru S, de Queiroz Prado R, Ricciardi A, Sciurba J, Kupritz J, Moser M, Kamenyeva O, Nutman TB. House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins. PLoS Pathog. 2021 Mar 2;17(3):e1009337.

Gazzinelli-Guimaraes PH, de Queiroz Prado R, Ricciardi A, Bonne-Année S, Sciurba J, Karmele EP, Fujiwara RT, Nutman TB. Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development. J Clin Invest. 2019 Aug 5;129(9):3686-3701.

Lee SH, Chaves MM, Kamenyeva O, Gazzinelli-Guimaraes PH, Kang B, Pessenda G, Passelli K, Tacchini-Cottier F, Kabat J, Jacobsen EA, Nutman TB, Sacks DL. M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis. Sci Immunol. 2020 Apr 10;5(46):eaaz4415.

Gazzinelli-Guimarães PH, Bonne-Année S, Fujiwara RT, Santiago HC, Nutman TB. Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection. J Immunol. 2016 Oct 1;197(7):2772-9. doi: 10.4049/jimmunol.1600829. Epub 2016 Aug 26. PMID: 27566825; PMCID: PMC5026971.

Gazzinelli-Guimaraes PH, Nutman TB. Helminth parasites and immune regulation. F1000Res. 2018 Oct 23;7:F1000 Faculty Rev-1685.

Visit PubMed for a complete publication listing.

Section or Unit Name
Helminth Immunology Section
Lab/Program Name
Laboratory of Parasitic Diseases
First Name
Pedro
Last Name
Gazzinelli Guimaraes
Exclude from directory
Off
Section/Unit: Location
NIH Main Campus, Bethesda, MD
This Researcher/Clinician’s Person Page
Pedro H. Gazzinelli Guimaraes, Ph.D.
Parent Lab/Program
Laboratory of Parasitic Diseases
Program Description

Dr. Gazzinelli-Guimaraes’ research program has been focused on the regulation of the immune response to helminth parasitic infections and to the pathogenesis of allergic diseases. 
We have a  specific interest in understanding the plasticity and specificity of circulating peripheral and tissue-resident effector Th2 cells driven by helminth antigens and/or allergens, as well as to understand the role of the effector Th2 subsets in the establishment of tissue Type-2-mediated inflammation using both mouse models and human studies. These studies aim to identify potential targets for the development of selective immunotherapy that could prevent chronic helminth infection or that could diminish allergic inflammation.

Selected Publications

Kupritz J, Angelova A, Nutman TB, Gazzinelli-Guimaraes PH. Helminth-Induced Human Gastrointestinal Dysbiosis: a Systematic Review and Meta-Analysis Reveals Insights into Altered Taxon Diversity and Microbial Gradient Collapse. mBio. 2021 Dec 21;12(6):e0289021.

Gazzinelli-Guimaraes PH, Bennuru S, de Queiroz Prado R, Ricciardi A, Sciurba J, Kupritz J, Moser M, Kamenyeva O, Nutman TB. House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins. PLoS Pathog. 2021 Mar 2;17(3):e1009337.

Gazzinelli-Guimaraes PH, de Queiroz Prado R, Ricciardi A, Bonne-Année S, Sciurba J, Karmele EP, Fujiwara RT, Nutman TB. Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development. J Clin Invest. 2019 Aug 5;129(9):3686-3701.

Lee SH, Chaves MM, Kamenyeva O, Gazzinelli-Guimaraes PH, Kang B, Pessenda G, Passelli K, Tacchini-Cottier F, Kabat J, Jacobsen EA, Nutman TB, Sacks DL. M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis. Sci Immunol. 2020 Apr 10;5(46):eaaz4415.

Gazzinelli-Guimarães PH, Bonne-Année S, Fujiwara RT, Santiago HC, Nutman TB. Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection. J Immunol. 2016 Oct 1;197(7):2772-9. doi: 10.4049/jimmunol.1600829. Epub 2016 Aug 26. PMID: 27566825; PMCID: PMC5026971.

Gazzinelli-Guimaraes PH, Nutman TB. Helminth parasites and immune regulation. F1000Res. 2018 Oct 23;7:F1000 Faculty Rev-1685.

Visit PubMed for a complete publication listing.

Major Areas of Research
  • Interaction between allergen- and helminth-driven type-2 immune responses
  • Biomarkers for helminth antigens- and allergens-specific human Th2 cells subsets
  • Multiomic profiling and TCR repertoire diversity of effector Th2 cells in the context of allergic diseases and helminth infections in both human studies and experimental models
  • Mechanisms of type-2 immune response induced by helminth infection and allergic sensitization in the lung tissue of experimental models
  • Influence of helminth infections on the regulation of the immune response of allergic individuals

Global Vaccine and Immunization Research Forum Presentations

Subscribe to