Principal investigator: Wesley Sundquist, Ph.D., University of Utah
This center is using computational and experimental methods to analyze HIV molecular complexes and determine how they interact with and commandeer cellular machinery to traffic throughout cells and tissues. By visually reconstructing virus particle assembly and trafficking, the center aims to develop HIV into a leading model for understanding how human viruses interact with cellular hosts, and to provide a platform for designing new therapeutic strategies.
Animation of ESCRT-III Subunits Unfolding and Being Recycled
This animation is showing how ESCRT-III subunits (green) are unfolded and recycled by the hexameric VPS4 ATPase (purple) and its LIP5 activator (yellow) during the process of HIV budding. The animation is by Janet Iwasa, based upon structures of ESCRT-III and VPS4/LIP5 determined in the CHEETAH Center.