Two molecules of restriction factor APOBEC3H form a sequence-independent complex with an RNA duplex.
Credit
CRNA
Two molecules of restriction factor APOBEC3H form a sequence-independent complex with an RNA duplex.
Credit:
CRNA
Principal investigator: Alice Telesnitsky, Ph.D., University of Michigan
This center studies the structural biology of viral RNA and its interactions with viral and host proteins. Because RNA is less amenable to structural analysis than proteins are, the researchers are developing approaches to overcome this technical challenge. Their work could help identify RNA-based targets for HIV treatments as well as shed light on the multiple biological functions of the viral genome.