Centers for HIV Structural Biology

The Centers for HIV Structural Biology, established in 2007 by the National Institute of General Medical Sciences (NIGMS), integrate a variety of techniques from structural biology, biochemistry and cell biology to capture in unprecedented detail the three-dimensional structures of HIV proteins and nucleic acids and their interactions with cellular components. This information will help elucidate how the different components interact and reveal new approaches for disrupting those interactions, potentially leading to new targets for HIV therapies and preventive vaccines.

The Center awards were transferred from NIGMS to NIAID in 2019 as a part of the consolidation of AIDS basic research projects in the NIAID Division of AIDS. The program was continued in 2022 with the funding of six new Centers. The Centers include research across the HIV life cycle, aiming, for example, to elucidate the mechanism the HIV envelope protein uses to enter a target cell, the interactions of virus structures with host proteins that either facilitate or antagonize infection, and the way that the HIV RNA genome folds into complex assemblies with other viral components before being packaged into newly formed virions. 

Main Areas of Focus

  • Structural Biology of HIV, molecular complexes, and HIV / host cell complexes including proteins, nucleic acids and pharmacologic inhibitors.
  • Identification of new host cell factors involved in HIV replication and restriction
  • Identification of new targets for anti-HIV drug development and vaccine design



RFA-AI-21-030: Centers for HIV Structural Biology (U54)
RFA-AI-22-050: Molecular Dynamics of HIV (R01 Clinical Trial Not Allowed)
NIAID Funding News: Molecular Dynamics of HIV Funding Opportunity 


Registration is Open

NIAID HIV Structural Biology Meeting

Monday, June 26 - Tuesday, June 27, 2023
NIH Natcher Conference Center Bethesda, MD

The meeting is free and open to all.

Contact Information

David McDonald, PhD, Basic Sciences Program, Division of AIDS, NIAID

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