Volunteer for COVID-19 Clinical Trials

We made history with safe and effective vaccines and we’ll keep working as long as there are people to protect, variants emerging, and research answers needed to keep us all safe. That means we still need you!

NIAID is conducting and supporting clinical trials evaluating therapies and vaccine candidates against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), as well as studies of people who have recovered from infection.

Featured COVID-19 Studies

Ongoing NIAID-supported COVID-19 Studies

Below is a selection of ongoing NIAID-supported studies. A frequently updated, comprehensive list of all COVID-19 clinical trials can be found on ClinicalTrials.gov.

Select from the options below based on the health category you fall under to find COVID-19 clinical study volunteer opportunities.

If you have never had a positive COVID-19 diagnostic test at any time in the past, you may qualify to volunteer for one of these studies. If you have had a positive COVID-19 test in the past—including if you had no symptoms but tested positive—you may qualify for studies that are seeking volunteers who have recovered from COVID-19.

These studies are seeking volunteers who may be exposed to SARS-CoV-2, the virus that causes COVID-19, in their everyday activities:

Systemic Allergic Reactions to SARS-CoV-2 Vaccination

  • Study Goal: To determine whether highly allergic people or people with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely to have an allergic reaction to the new Pfizer-BioNTech and Moderna COVID-19 vaccines than other people.
  • Locations: Clinical research sites are located throughout the United States.
  • Sign up to Volunteer: Fill out the volunteer questionnaire to find out if you qualify, and you will be matched with the appropriate research site.

Vaccine and Monoclonal Antibody Studies for the Prevention of COVID-19

  • Study Goal: To find safe and effective vaccines and monoclonal antibodies for SARS-CoV-2, the virus that causes COVID-19.
  • Locations: Clinical research sites are located throughout the United States.
  • Sign up to Volunteer: Fill out the volunteer questionnaire to find out if you qualify, and you will be matched with the appropriate research site.

Working or living with others who have COVID-19 puts you at high risk of exposure. If you live with someone who has tested positive for SARS-CoV-2, the virus that causes COVID-19, or you work in a medical or assisted living facility where you are caring for COVID-19 patients, you may qualify for these studies.

COVID-19 Antibody Treatment Study for Preventing SARS-CoV-2 Infection in Nursing Home Residents and Staff

  • Study Goal: To find out whether LY-CoV555, a potential COVID-19 antibody treatment, can prevent SARS-CoV-2 infection among people at high risk of exposure because they live or work in a skilled nursing or assisted living facility.
  • Locations: Clinical research sites are distributed throughout the United States.
  • Sign up to Volunteer: Fill out the volunteer questionnaire to find out if you qualify and you will be matched with the appropriate research site.
  • Official Study Title: A Study of LY3819253 (LY-CoV555) in Preventing SARS-CoV-2 Infection and COVID-19 in Nursing Home Residents and Staff (BLAZE-2)

COVID-19-Recovered Specimen Collection Study

  • Study Goal: To further define and understand specific immune responses from blood samples donated by volunteers who are fully recovered from a confirmed COVID-19 infection.
  • Locations: NIH Clinical Center in Bethesda, Maryland
  • Sign Up to Volunteer: Visit the COVID-19-Recovered Specimen Collection Study page for eligibility and contact information.
  • Official Study Title: Apheresis and Specimen Collection Procedures to Obtain Plasma, Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens for Research Studies

Study of How COVID-19 Affects Blood Cells and the Immune System

  • Study Goal: To study how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.
  • Locations: Washington, DC Metro Area
  • Sign Up to Volunteer: Visit the Study of How COVID-19 Affects Blood Cells and the Immune System page for eligibility and contact information
  • Official Study Title: COVID-19–associated Lymphopenia Pathogenesis Study in Blood (CALYPSO)

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

  • Study Goal: To study the long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.
  • Locations: The NIH in Bethesda, Maryland
  • Sign Up to Volunteer: Visit the Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery page for eligibility and contact information
  • Official Study Title: Longitudinal Study of COVID-19 Sequelae and Immunity (RECON_19)

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

  • Study Goal: To assess the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and investigate whether prior SARS-CoV-2 infection may change that response.
  • Locations: The NIH in Bethesda, Maryland
  • Sign Up to Volunteer: Visit our Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery page for eligibility and contact information.
  • Official Study Title: Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine

These studies are seeking volunteers who have had a confirmed diagnostic test for COVID-19 but are not sick enough to need hospitalization.

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

Drug Treatment Study of Individuals With Mild COVID-19

  • Study Goal: To find out if an experimental drug called NT-I7 is safe for people with COVID-19. We also want to see if it might help treat COVID-19 by supporting the immune system.
  • Locations: The NIH in Bethesda, Maryland
  • Sign Up to Volunteer: Visit our Drug Treatment Study of Individuals With Mild COVID-19 page for eligibility and contact information.
  • Official Study Title: A double-blind, randomized, placebo-controlled, phase 1, single-dose, dose-escalating trial of long-acting recombinant human IL-7 (NT-I7) for COVID-19 (SPESELPIS)

Drug Treatment Study for Outpatients With COVID-19

  • Study Goal: To look at the safety and effectiveness of different drugs in treating COVID-19 in outpatients. Participants in the study will receive an experimental therapy or a placebo.
  • Locations: See the study page on ClinicalTrials.gov for locations.
  • Sign Up to Volunteer: Visit our Drug Treatment Study for Outpatients With COVID-19 page for eligibility and contact information.
  • Official Study Title: Adaptive Platform Treatment Trial for Outpatients With COVID-19 (Adapt Out COVID or ACTIV-2)

Genetics of COVID-19 Susceptibility and Manifestations

  • Study Goal: To learn more about how genetics play a role in the severity of COVID-19 in different people. We hope to use this information to develop therapies to reduce the severity of symptoms of COVID-19 in some people.
  • Locations: Participants will complete the health survey over the phone. Local participants may come to the NIH Clinical Center in Bethesda, Maryland, for the blood draw, while others may visit their local Quest lab for the blood draw. For either option, we cover the cost of the blood draw.
  • Sign Up to Volunteer: Visit our Genetics of COVID-19 Susceptibility and Manifestations page for eligibility and contact information.
  • Official Study Title: Genetics of COVID-19 Susceptibility and Manifestations (COVIDcode)

Observational Study of Coronavirus Infection and Multisystem Inflammatory Syndrome in Children

  • Study Goal: To evaluate the short- and long-term health outcomes of SARS-CoV-2 infection in children and young adults under 21, including multisystem inflammatory syndrome in children (MIS-C), and to characterize the immunologic pathways associated with different disease presentations and outcomes.
  • Locations: Visit the study page on ClinicalTrials.gov for locations.
  • Sign Up to Volunteer: Visit the study page on ClinicalTrials.gov for locations.
  • Official Study Title: COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

Study of How COVID-19 Affects Blood Cells and the Immune System

  • Study Goal: To learn how SARS-CoV-2, the virus that causes COVID-19, affects the body—specifically how it affects blood cells and the immune system.
  • Locations: Washington, DC, Metro Area
  • Sign Up to Volunteer: Visit our Study of How COVID-19 Affects Blood Cells and the Immune System page for eligibility and contact information.
  • Official Study Title: COVID-19-Associated Lymphopenia Pathogenesis Study in Blood (CALYPSO)

These studies are occurring in specific hospitals and seeking volunteers with severe COVID-19. Volunteers will typically be connected to the studies through their medical care providers.

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

  • Study Goal: To evaluate the success of different investigational treatments for adults hospitalized for severe COVID-19.
  • Locations: This study will be conducted in up to 40 sites throughout the United States.
  • Sign Up to Volunteer: Visit our Big Effect Trial (BET) for Finding Promising Treatments of COVID-19 for eligibility and contact information.
  • Official Study Title: Big Effect Trial for the Treatment of COVID-19 (ACTIV-5/BET-B)

Immune Response Tracking in Hospitalized COVID-19 Patients

  • Study Goal: To track the immune responses of people hospitalized with COVID-19.
  • Locations: This study will be at 10 research sites across the United States.
  • Sign Up to Volunteer: This study is enrolling only by invitation.
  • Official Study Title: Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)

Observational Study of Coronavirus Infection and Multisystem Inflammatory Syndrome in Children

  • Study Goal: To evaluate the short- and long-term health outcomes of SARS-CoV-2 infection in children and young adults under 21, including multisystem inflammatory syndrome in children (MIS-C), and to characterize the immunologic pathways associated with different disease presentations and outcomes.
  • Locations: Visit the study page on ClinicalTrials.gov for locations.
  • Sign Up to Volunteer: Visit the study page on ClinicalTrials.gov for locations.
  • Official Study Title: COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

Study of How COVID-19 Affects Blood Cells and the Immune System

  • Study Goal: To study how SARS-CoV-2, the virus that causes COVID-19, affects the body—specifically how it affects blood cells and the immune system.
  • Locations: Washington, DC, Metro Area
  • Sign Up to Volunteer: Visit our Study of How COVID-19 Affects Blood Cells and the Immune System page for eligibility and contact information.
  • Official Study Title: COVID-19-Associated Lymphopenia Pathogenesis Study in Blood (CALYPSO)

Other COVID-19 Clinical Trials Resources

Health and Human Services has created a new Combat COVID web portal containing current information on clinical trials that people can participate in, as well as processes for donating blood and plasma, that will lead to prevention and treatment breakthroughs to benefit everyone.

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