Investigators' Research Areas

General areas of research interest of the principal investigators in DIR are listed below. The investigators' names link to their NIAID Web pages, which provide research descriptions, links to publications, and contact information.

View list of lab abbreviations

Name Areas of Expertise
Barry III, Clifton E., Ph.D.
Senior Investigator, LCID
Mycobacterium tuberculosis, TB drug development, MDR-TB, XDR-TB
Belkaid, Yasmine, Ph.D.
Investigator, LPD
Tregs, regulatory T cells, parasitic diseases, Foxp3
Bennett, John E., M.D.
Senior Investigator, LCID
Candida, fungal diseases, drug resistance, azole, drug transport
Bennink, Jack R., Ph.D.
Senior Investigator, LVD
Viral immunology, antigen presentation, vaccinia, influenza, immunodominance
Berger, Edward A., Ph.D.
Senior Investigator, LVD
Viral envelope-receptor interactions, HIV coreceptors, viral coreceptors, KSHIV, microbicide
Bloom, Marshall, M.D.
Senior Investigator, LPVD
Tickborne encephalitis virus, interferon, JAK-STAT signal transduction
Bolland, Silvia, Ph.D.
Investigator, LIG
Autoimmunity, lupus, SLE, glomerulonephritis, FCR
Bouamr, Fadila, Ph.D.
Investigator, LMM
Retroviral assembly, HIV-1 Gag, HTLV-I Gag, virus-host interactions
Caldwell, Harlan, Ph.D.
Laboratory Chief, LICP
Chlamydia vaccine development, chlamydia, trachoma
Caughey, Byron, Ph.D.
Senior Investigator, LPVD
Transmissible spongiform encephalopathies, prion, chronic wasting disease, scrapie, Creutzfeldt-Jakob disease, BSE
Celli, Jean, Ph.D.
Investigator, LICP
Fransicella tularensis, tularemia, Brucella, brucellosis
Chanock, Robert, M.D.
Senior Investigator, LID
Vaccine development, respiratory viruses
Chesebro, Bruce, M.D.
Laboratory Chief, LPVD
Transmissible spongiform encephalopathies, prion protein retroviral brain diseases
Cohen, Jeffrey I., M.D.
Senior Investigator, LCID
Chickenpox, shingles, zoster, varicella, herpesvirus, EBV, HSV, VZV
Collins, Peter, Ph.D.
Senior Investigator, LID
Human metapneumovirus, paramyxovirus, live attenuated vaccine, pediatric infectious disease, RSV, parainfluenza
Coligan, John E., Ph.D.
Senior Investigator, LAD
Receptor cell biology, inhibitory receptors, LAIR (CD305), IRp60 (CD300), NK cell
Connors, Mark, M.D.
Senior Clin. Investigator, LIR
HIV/AIDS, long-term non-progressors, HIV immunity, cytotoxic T cell, HIV vaccine
Davey, Richard T., M.D.
Senior Clin. Investigator, LIR
HIV/AIDS clinical research, HAART, antiretroviral therapy, immune-based therapy, IL-2, interrupted therapy
DeLeo, Frank R., Ph.D.
Senior Investigator, LHBP
Phagocytosis, neutrophil, Staphylococcus aureus,Streptococcus pyogenes, inflammation, innate immunity
Desai, Sanjay, M.D., Ph.D.
Investigator, LMVR
Malaria parasite nutrient acquisition, ion transport, electrophysiology, Plasmodium falciparum
Druey, Kirk M., M.D.
Senior Investigator, LAD
Asthma, lung, airway smooth muscle, G proteins, RGS proteins
Ehrenfeld, Elvera, Ph.D.
Senior Investigator, LID
Poliovirus, rhinovirus, Coxsackie virus, RNA replication, picornavirus
Emerson, Suzanne, Ph.D.
Senior Investigator, LID
Hepatitis molecular biology, hepatitis E, hepatitis C, infectious cDNA clones, monoclonal antibodies
Evans, Leonard, Ph.D.
Senior Investigator, LPVD
Retrovirus molecular biology, leukemia, neuropathology, MuLV, endogenous retroviruses
Farber, Joshua, M.D.
Senior Investigator, LMI
Chemokines, receptors, NK cells, dendritic cells, leukocyte trafficking
Farci, Patrizia, M.D.
Senior Investigator, LID
Hepatitis C
Fauci, Anthony S., M.D.
Laboratory Chief, LIR
HIV immunopathogenesis, AIDS, HIV latency
Fowlkes, B.J., Ph.D.
Senior Investigator, LI
T-cell development, thymus, thymocytes, T cells, TCR, Notch, presenilin
Gallin, John I., M.D.
Senior Investigator, LHD
Granulomatous disorders, inherited mmunodeficiency, inflammation, chronic granulomatous disease
Garboczi, David, Ph.D.
Investigator, LIG
T-cell receptors, protein crystallography, malaria, receptor-ligands, parasite surface proteins, X-ray crystallography
Germain, Ronald N., M.D., Ph.D.
Deputy Chief, LI
T-cell receptor, MHC molecule, signal transduction, lymphocyte homeostasis, computer modeling, imaging
Gherardini, Frank, Ph.D.
Senior Investigator, LZP
Burkholderia malleiB. pseudomallei, borrelia, glanders, melioidosis
Grigg, Michael, Ph.D.
Investigator, LPD
Toxoplasma gondii, toxoplasmosis
Hackstadt, T. W., Ph.D.
Senior Investigator, LICP
Rickettsia, Rocky Mountain spotted fever, Chlamydia trachomatis, trachoma, STI
Hasenkrug, Kim, Ph.D.
Investigator, LPVD
Retroviral immunology, persistent virus, Friend virus, erythroleukemia, regulatory T cells,
Heinzen, Robert, Ph.D.
Investigator, LICP
Coxiella burnetii, Q fever, endocarditis, cell biology, intracellular parasitism, vesicle trafficking
Hinnebusch, Joe, Ph.D.
Senior Investigator, LZP
Yersinia pestis, plague, arthropod-borne transmission,Xenopsylla cheopis, fleas
Hirsch, Vanessa M., D.V.M., S.D.
Senior Investigator, LMM
AIDS vaccine development, SIV phylogeny
Holland, Steven, M.D.
Laboratory Chief, LCID
Mycobacteria, NTM, chronic granulomatous disease, Job's syndrome, immune disorders
Inman, John K., Ph.D.
Senior Investigator, LI
 
Jackson, Sharon, M.D.
Investigator, LHD
Hematopoietic progenitor, dendritic cell, granulocyte, macrophage, APC, inflammation, apoptosis
Jain, Ashish, M.D.
Investigator, LHD
Primary immune deficiency, NEMO
Jeang, Kuan Teh, M.D., Ph.D.
Senior Investigator, LMM
AIDS, adult T-cell leukemia, cancer, HIV-1, HTLV-I, Tat, Tax, retrovirus
Jin, Tian, Ph.D.
Investigator, LIG
Live cell imaging, fluorescence resonance energy transfer, quantitative modeling, HIV entry receptors
Keane-Myers, Andrea, Ph.D.
Investigator, LAD
Allergy, allergic asthma
Kehrl, John H., M.D.
Senior Investigator, LIR
RGS, G-protein, chemokine, chemotaxis, lymphocytes
Kelsall, Brian, M.D.
Senior Investigator, LMI
IL-12, CR3, complement, dendritic cell, Peyer's patch, mucosal immunity, chemokine, autoimmunity
Kozak, Christine, Ph.D.
Senior Investigator, LMM
Leukemia viruses, mouse genomics, retroviruses, mouse leukemia virus, MuLV
Kristie, Thomas, Ph.D.
Senior Investigator, LVD
Herpes, HSV, transcription, gene regulation, latency
Kwon-Chung, Kyung, Ph.D.
Senior Investigator, LCID
Cryptococcus, aspergillus, fungi, fungal diseases
Lai, Ching-Juh, Ph.D.
Senior Investigator, LID
Dengue, flaviviurses, antibody repertoire cloning, chimpanzee Fabs, humanized monoclonal antibodies
Lane, H. Clifford, M.D.
Senior Investigator, LIR
Biodefense, anthrax, smallpox, SARS, influenza, AIDS
Lenardo, Michael, M.D.
Senior Investigator, LI
T regulatory cells, Tregs, suppression, lymphocyte, apoptosis, receptor, caspase-8, NF-κB, Bcl-2
Leppla, Stephen, Ph.D.
Senior Investigator, LBD
Anthrax, toxin, protease, mutagenesis, Bacillus anthracis
Leto, Thomas, Ph.D.
Senior Investigator, LHD
NADPH oxidase, Nox, phagocyte biochemistry, chronic granulomatous disease, innate immunity, cystic fibrosis
Lobanenkov, Victor, Ph.D.
Senior Investigator, LIP
Cancer, BORIS, CTCF, DNA methylation
Long, Eric O., Ph.D.
Senior Investigator, LIG
NK cells, cell adhesion, cytotoxicity, degranulation, HLA-C, HLA, immune synapse, inhibitory receptor
McBride, Alison, Ph.D.
Senior Investigator, LVD
Papillomaviruses, HPV, keratinocyte biology
McCutchan, Thomas, Ph.D.
Senior Investigator, LMVR
Malaria, antibiotics, thiopeptides, protein synthesis regulation, plasmodium development
Mage, Rose G., Ph.D.
Senior Investigator, LI
Autoimmune diseases, rabbit, splenic germinal centers, rabbit appendix
Malech, Harry L., M.D.
Laboratory Chief, LHD
Gene therapy, chronic granulomatous disease, X-linked SCID, stem cells, WHIM syndrome, lentiviral vector
Margulies, David H., M.D., Ph.D.
Senior Investigator, LI
MHC, T cell receptors, NK receptors, transgenic mice, autoimmunity, autoimmune gastritis
Martin, Malcolm A., M.D.
Laboratory Chief, LMM
HIV pathogenesis, HIV animal models, HIV vaccines, neutralizing antibody, SIV/HIV chimeric viruses, SHIV
Matzinger, Polly, Ph.D.
Senior Investigator, LCMI
Immunology, tolerance, transplantation, dendritic cells, oral tolerance, self tolerance, hemophilia, danger model
Metcalfe, Dean D., M.D.
Laboratory Chief, LAD
Mastocytosis, mast cells, serotonin, ROS, nitric oxide, asthma, allergy, basophils, Th2 cells, IL-4, anaphylaxis
Miller, Louis H., M.D.
Chief, MVDB
Malaria pathogenesis, malaria vaccines, cytoadherence to placenta and endothelium, red cell invasion
Morse, III, Herbert C., M.D.
Laboratory Chief, LIP
Cancer, immune disorders, lymphoma, retroviral pathogenesis, B cells
Moss, Bernard, M.D., Ph.D.
Laboratory Chief, LVD
Poxvirus pathogenesis, poxvirus immunity, vaccinia virus, transcription, MVA, smallpox vaccine
Muljo, Stefan Ph.D.
Senior Investigator, LI
​Hematopoietic stem cells, B cell development, post-transcriptional regulation, non-coding RNAs, RNA-binding proteins
Murphy, Brian R., M.D.
Laboratory Co-Chief, LID
RSV, parainfluenza virus, croup, bronchiolitis, vaccines, live-attenuated virus vaccines, dengue, WNV, TBEV
Murphy, Philip M., M.D.
Laboratory Chief, LMI
Inflammation, chemotaxis, chemokine, AIDS, G protein-coupled receptor, Alzheimer's disease, atherosclerosis
Nash, Theodore, M.D.
Senior Investigator, LPD
Giardia lamblia, microsporidium, intestinal infection, diarrhea, protozoa, parasite
Nutman, Thomas, M.D.
Assistant Chief, LPD
Filaria, loiasis, filariasis, onchocerciasis, strongyloidiasis, albendazole, lymphedema, cytokines
Otto, Michael, Ph.D.
Investigator, LHBP
Staphylococcus epidermidisStaphylococcus aureus, MRSA, catheter infection, biofilms, quorum sensing
Pierce, Susan K., Ph.D.
Laboratory Chief, LIG
B lymphocyte, lipid rafts, B cell receptor, BCR, FRET imaging, TIRF microscopy, plasma cells, malaria vaccine
Pierson, Theodore, Ph.D.
Investigator, LVD
Flavivirus, West Nile virus, dengue, humoral immune response, antibody, antibody-mediated enhancement of infection
Pletnev, Alexander, Ph.D.
Senior Investigator, LID
Neurotropic flaviviruses, tickborne encephalitis virus, West Nile virus, live-attenuated virus, vaccine research
Polis, Michael, M.D.
Senior Clin. Investigator, LIR
HIV/AIDS, emerging infections, tuberculosis, international collaborations, clinical research
Portis, John, M.D.
Senior Investigator, LPVD
Retrovirus, brain, spongiform, neurodegeneration, ER stress, retrovirus-induced CNS pathology
Priola, Suzette, Ph.D.
Senior Investigator, LPVD
Transmissible spongiform encephalopathies, scrapie, prion diseases, TSE therapeutics, TSE species barriers
Prussin, Calman, M.D.
Investigator, LAD
Asthma, allergy, T cells, tolerance, therapy, Th2 cells, IgE, IL-4, immunomodulation
Purcell, Robert H., M.D.
Laboratory Co-Chief, LID
Hepatitis viruses, select agents, vaccines, antibodies, Kawasaki disease, HAV, HBV, HCV, HEV
Quinn, Thomas, M.D., M.Sc.
Senior Investigator
Chlamydia, sexually transmitted diseases, STIs, HIV, AIDS, heterosexual transmission, international AIDS
Race, Richard, D.V.M.
Senior Investigator, LPVD
Prion protein, scrapie, TSE, BSE, CWD, CJD, viral pathogenesis, prion transmission mechanisms
Rosa, Patricia, Ph.D.
Senior Investigator, LZP
Borrelia burgdorferi, spirochete, Lyme disease, molecular genetics, tickborne, linear plasmids, adaptive response
Rosenberg, Helene, M.D., Ph.D.
Senior Investigator, LAD
Eosinophil biology, IL-5, asthma, helminth, ribonucleases, hematopoiesis, pneumovirus, inflammation
Sacks, David L., Ph.D.
Senior Investigator, LPD
Cutaneous leishmaniasis, leishmania vector biology, sand flies, IL-12, IL-10, Tregs, dendritic cells, DNA vaccines, galectin
Sher, Alan, Ph.D.
Laboratory Chief, LPD
Toxoplasmosis, immunoregulation, dendritic cells,Mycobacterium tuberculosisTrypanosoma cruzi, Toll-like receptors, MyD88
Shevach, Ethan M., M.D.
Senior Investigator, LI
Control of autoimmunity by regulatory T cells, T-cell activation, cell surface antigens
Siebenlist, Ulrich K., Ph.D.
Senior Investigator, LIR
Mechanisms of activation of NF-κB, signal transduction, Bcl-3, BAFF
Silver, Jonathan E., M.D.
Senior Investigator, LMM
Retrovirus- cell interactions, HIV, MLV, virus receptor
Steele-Mortimer, Olivia, Ph.D.
Senior Investigator, LICP
Akt/PKB, apoptosis, cell biology, gastroenteritis, Salmonella enterica
Strebel, Klaus A., Ph.D.
Senior Investigator, LMM
Retrovirus genes, HIV-1, Vpu, Vif, virus-host interactions, accessory proteins, protein degradation, APOBEC3G
Strober, Warren, M.D.
Senior Investigator, LHD
Inflammatory bowel disease, Crohn's disease, mucosal immunity, IL-12, CARD15 (NOD2), CARD 4 (NOD1), peptidoglycan
Su, Xinzhuan, Ph.D.
Senior Investigator, LMVR
Malaria drug resistance;​ plasmodium sexual development; malaria genetics, genomics, evolution, population genetics
Sun, Peter, Ph.D.
Senior Investigator, LIG
Structural immunology, DC-SIGN, gp120, BIAcore, X-ray crystallography
Taubenberger, Jeffrey, M.D., Ph.D.
Senior Investigator, LID
Influenza pathogenesis, pandemic influenza, influenza virus virulence factors
Wellems, Thomas E., M.D., Ph.D.
Laboratory Chief, LMVR
Malaria drug resistance, disease virulence, genetics; hemoglobinopathies, antigenic variation, chloroquine, quinine
Wynn, Thomas A., Ph.D.
Senior Investigator, LPD
Schistosomiasis pathogenesis, Schistosoma, granuloma, fibrosis, IL-13, IL-10, IL-12
Yewdell, Jonathan W., M.D., Ph.D.
Senior Investigator, LVD
Viral immunity, antigen presentation/processing, MHC class I molecules, ubiquitin, proteasome, vaccines

List of abbreviations

Abbreviation Definition
CMB Comparative Medicine Branch
CRC Mark Hatfield Clinical Research Center
DIR Division of Intramural Research
LAD Laboratory of Allergic Diseases
LBD Laboratory of Bacterial Diseases
LCID Laboratory of Clinical Infectious Diseases
LCMI Laboratory of Cellular and Molecular Immunology
LHBP Laboratory of Human Bacterial Pathogenesis
LHD Laboratory of Host Defenses
LI Laboratory of Immunology
LICP Laboratory of Intracellular Parasites
LID Laboratory of Infectious Diseases
LIG Laboratory of Immunogenetics
LIP Laboratory of Immunopathology
LIR Laboratory of Immunoregulation
LMI Laboratory of Molecular Immunology
LMM Laboratory of Molecular Microbiology
LMVR Laboratory of Malaria and Vector Research
LPD Laboratory of Parasitic Diseases
LPVD Laboratory of Persistent Viral Diseases
LVD Laboratory of Viral Diseases
LZP Laboratory of Zoonotic Pathogens
MVDB Malaria Vaccine Development Branch
RML Rocky Mountain Laboratories
RMVB Rocky Mountain Veterinary Branch
RTB Research Technologies Branch
TW Twinbrook
Content last reviewed on February 3, 2017