Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.
Note: Council approval does not guarantee that a concept will become an initiative.
Table of Contents
Fiscal Year (FY) 2024 Division of Allergy, Immunology, and Transplantation (DAIT) Concept
FY 2025 DAIT Concepts
- Computational Models of Influenza Immunity
- Development of Candidate Radiation/Nuclear Medical Countermeasures (MCMs)
- Fc-Dependent Mechanisms of Antibody-Mediated Killing
- RNCP Portfolio-Wide Dosimetry Verification Services
- Notice of Special Interest (NOSI)—Collaborative Cross (CC) Mouse Model Generation and Discovery of Immunoregulatory Mechanisms
- Notice of Special Interest (NOSI)—Immune Responses to Arthropod Feeding on Vertebrate Hosts
- Notice of Special Interest (NOSI)—Understanding the Immune Functions of DEAD/H-box Helicases
Notice of Special Interest (NOSI)—Research on Early Allergy Determinants Using Biosamples from the SUNBEAM Birth Cohort
For the published notice of special interest, check the July 25, 2023 Guide notice, Notice of Special Interest (NOSI): Research on Early Allergy Determinants using Biosamples from the SUNBEAM Birth Cohort.
Computational Models of Influenza Immunity
For the published request for applications, check the September 13, 2023 Guide announcement, Computational Models of Influenza Immunity (U01, Clinical Trial Not Allowed).
Development of Candidate Radiation/Nuclear Medical Countermeasures (MCMs)
For the published request for applications, check the October 24, 2023 Guide announcement, Development of Candidate Radiation/Nuclear Medical Countermeasures (MCMs) (U01, Clinical Trial Not Allowed).
Fc-Dependent Mechanisms of Antibody-Mediated Killing
For the published request for applications, check the September 26, 2023 Guide announcement, Fc-Dependent Mechanisms of Antibody-Mediated Killing (R01, Clinical Trial Not Allowed).
RNCP Portfolio-Wide Dosimetry Verification Services
Request for Proposals—proposed FY 2025 initiative
Contact:
Tom Bahrami
bahramit@niaid.nih.gov
Objective: This initiative will continue the harmonization of radiation dosimetry methodology across the Radiation and Nuclear Countermeasures Program (RNCP) portfolio and will lead to more reliable and reproducible data from RNCP-funded projects.
Description: This initiative will support continued funding of an RNCP portfolio-wide dosimetry verification resource.
Notice of Special Interest (NOSI)—Collaborative Cross (CC) Mouse Model Generation and Discovery of Immunoregulatory Mechanisms
Notice of Special Interest (NOSI)—proposed FY 2025 initiative
Contact:
Joy Liu
liujoy@niaid.nih.gov
Objective: To support the use of Collaborative Cross (CC) mouse lines to advance understanding of host genetics involved in immune regulation and function in response to infectious, immune-mediated, or allergic diseases; identify novel mouse models for infectious, immune-mediated, or allergic diseases; and further develop CC mouse lines that more faithfully reproduce human immune responses.
Description: This initiative will
- Continue supporting R21 applications as outlined in the current NOSI, NOT-AI-21-071, for the development and use of the CC mouse resource for immunologic investigations in areas of interest to NIAID.
- Support potential follow-up R01 applications from the current R21 projects funded by this program and new R01 projects that employ the CC mouse resource to identify genetic factors contributing to the variations in disease susceptibility and/or host immunity.
- Support new R01 preclinical projects using human samples to validate findings in the CC and CC-RIX mice.
Notice of Special Interest (NOSI)—Immune Responses to Arthropod Feeding on Vertebrate Hosts
Notice of Special Interest (NOSI)—proposed FY 2025 initiative
Contact:
Joy Liu
liujoy@niaid.nih.gov
Objective: The scientific objectives of this initiative are to
- Understand the immunological events in the vertebrate host that occur during and after feeding by hematophagous and ectoparasitic arthropods at the bite site (skin) and systemically.
- Identify and characterize arthropod salivary components and their effect on immune modulation.
- Determine the factors and mechanisms responsible for immune-mediated disease (i.e., allergy, such as alpha-gal syndrome, dermatitis) triggered by hematophagous or ectoparasitic arthropods.
- Utilize discovered salivary factors as targets to regulate immune responses and/or control vector-born pathogens’ replication and transmission.
The long-term goals of this NOSI include developing a deeper understanding of regulation of host immune responses; identifying novel molecules from vector saliva that can be used to manipulate immunity; discovering potential targets for the prevention or treatment of allergy induction following exposure to vector salivary components; and generating insights that will enable the development of novel vaccines, therapeutics, and diagnostics (e.g., arthropod exposure) against arthropod vectors and/or vector-borne-diseases.
Description: This initiative will support studies of the immunological events in the vertebrate host that occur during and after feeding by hematophagous and ectoparasitic arthropods at the bite site (skin) and systemically. Arthropod salivary factors, including proteins, RNA, peptides, lipids, nucleosides, and small molecules, have been shown to regulate the vertebrate host response. Only a few of these molecules have been characterized in select arthropod vectors and additional types of factors are likely to exist. The NOSI encourages studies to characterize and better understand the role of known and novel arthropod salivary factors in immune modulation associated with vector-borne infections and related immune-mediated diseases (e.g., alpha-gal syndrome) at both the bite site and systemically. There are no changes from the previous NOSI.
Notice of Special Interest (NOSI)—Understanding the Immune Functions of DEAD/H-box Helicases
Notice of Special Interest (NOSI)—proposed FY 2025 initiative
Contact:
Joy Liu
liujoy@niaid.nih.gov
Objective: The objective of this initiative renewal is to continue to gain a better understanding of the expression, function, and regulation of DEAD/H-box helicases in immune homeostasis and activation/function.
Description: This NOSI renewal will continue to
- Support investigation of the role of DEAD/H-box helicases in innate immune sensing and modulation of innate and adaptive immune signaling pathways and gene expression.
- Improve understanding of the mechanisms by which DEAD/H-box helicases control immune cell development, proliferation, migration, composition, and function.