Major Areas of Research
- Single cell RNASeq and CITEseq analysis of innate and adaptive immune responses
- Dynamics of IG and TR repertoires in response to vaccination and infection
- Somatic hypermutation and antibody phylogenetics
- Impact of IG genetics on immune outcomes
The Integrative Bioinformatics of Immune Systems (IBIS) Core is the central bioinformatic resource for all repertoire and “omics” studies in the VRC, offering coordinated staffing and planning for multi-section and external collaborations, such as the ongoing SARS-CoV-2 response efforts. Specific research areas in the IBIS Core include transcriptomic analysis of both innate and adaptive immune cells, T cell receptor repertoire analysis, B cell receptor sequence and phylogenetic analysis, and analysis of immune cell population dynamics. In addition, we work closely with the Genome Analysis, Humoral Immunology, Structural Bioinformatics Cores, and the Vaccine Immunology Program to prioritize experiments and analyses that will best advance the scientific objectives of the VRC.
Dr. Schramm earned his Ph.D. from the University of Pennsylvania in 2012 and completed a postdoctoral fellowship at Columbia University prior to joining the VRC as a staff scientist in 2016. Dr. Schramm has been a pioneer in the longitudinal phylogenetic analysis of B cell clonal lineages and developed the SONAR analysis suite to facilitate those studies. He also has significant research interests in IG V gene substitution profiles and immunogenetics. As chief of the IBIS Core, Dr. Schramm designs and leads large-scale scRNASeq analyses of innate and adaptive immune cells dynamics in infection and vaccination. Beyond the VRC, Dr. Schramm is a founding member of the AIRR Community organization and serves as co-chair of the Software Working Group.
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