Jonathan Lyons, M.D.

Assistant Clinical Investigator
Genetics and Pathogenesis of Allergy Section

Major Areas of Research

  • To investigate the consequences of altered glycosylation in atopy and allergic inflammation
  • To study the structural variation, altered expression, and function of  the glycoprotein tryptase, a mediator released by mast cells and involved in allergic reactions
  • To develop novel targeted therapeutic approaches for individuals with severe allergy and mast cell-associated disorders

Program Description

Working in the Milner lab since 2014, Dr. Lyons has been involved in the identification of novel genetic causes for allergic inflammation and immune dysregulation. These include phosphoglucomutase 3 (PGM3) deficiency, an autosomal recessive congenital disorder of glycosylation that leads to a complex hyper-IgE phenotype, and tryptasemia, a variably penetrant disorder associated with dominantly inherited elevations in basal serum tryptase. Deciphering how changes in glycosylation may lead to atopy and immune dysregulation and affect allergic reactions is currently a major area of focus. A second area of focus is on the role that isoforms of the glycoprotein tryptase may play on influencing clinical phenotypes and allergic reactions.


Jonathan Lyons received his undergraduate education at Pomona College and Jesus College, Cambridge, United Kingdon, where he spent two terms. He graduated with a B.A. in chemistry from Pomona College in 2003 and received an M.D. from the University of Southern California in 2007. Dr. Lyons completed residency training in internal medicine at the University of California, San Diego, in 2010, remaining an additional year as a chief medical resident. He concluded his formal medical training in 2014 at NIAID as a clinical fellow in allergy and immunology. Following completion of a fellowship, he was selected for the NIAID Transition Program in Clinical Research and is currently an assistant clinical investigator in the Laboratory of Allergic Diseases. Dr. Lyons is board certified in internal medicine and allergy/immunology, a member of the Clinical Immunology Society, and a member of the American Academy of Allergy, Asthma & Immunology, where he serves on the Genetics, Molecular Biology, and Epidemiology Committee. He is an associate investigator on several clinical protocols and the principle investigator on a protocol to provide sugar supplementation to patients with glycosylation defects and immunologic disease.


Selected Publications

Lyons JJ, Milner JD, Rosenzweig SD. Glycans instructing immunity: an emerging role for altered glycosylation in clinical immunologyFront Pediatr. 2015 Jun 11;3:54.

Lyons JJ, Sun G, Stone KD, Nelson C, Wisch L, O’Brien M, Jones N, Lindsley A, Komarow HD, Bai Y, Scott LM, Cantave D, Maric I, Abonia JP, Rothenberg ME, Schwartz LB, Milner JD, Wilson TM. Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalitiesJ Allergy Clin Immunol. 2014 May;133(5):1471-4.

Zhang Y, Yu X, Ichikawa M, Lyons JJ, Datta S, Lamborn IT, Jing H, Kim ES, Biancalana MR, Wolfe LA, DiMaggio T, Matthews HF, Kranick SM, Stone KD, Holland SM, Reich DS, Hughes JD, Mehmet H, McElwee J, Freeman AF, Freeze HH, Su HC, Milner JD. Autosomal recessive PGM3 mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairmentJ Allergy Clin Immunol. 2014 May;133(5):1400-9, 1409.e1-5.

Tholpady A, Chiosea I, Lyons JJ, Baird K, Leitman SF. Systemic hypersensitivity reaction mimicking anaphylaxis after first filgrastim administration in a healthy donorTransfusion. 2013 May;53(5):1146-7.

Visit PubMed for a complete publication listing.

Content last reviewed on March 14, 2016