Sexually Transmitted Infections Information for Researchers

Sexually transmitted infections (STIs) are an important global health priority because of their devastating impact on women and infants and their inter-relationships with HIV/AIDS biologically and epidemiologically. The ultimate objective of NIAID-supported research is to develop effective prevention and treatment approaches to control STIs.

Funding Opportunities

NIAID is always accepting researcher-initiated applications. Connect with NIAID program officers about potential funding for STI research.

Program Officers

Program Officers for STIs can be found in the Enteric and Sexually Transmitted Infections Branch (ESTIB) of the Division of Microbiology and Infectious Diseases (DMID). For information on HSV basic research, see DMID's Virology Branch (VB).


Search our funding opportunities for STI-related grants

Resources for Researchers

NIAID provides a wide range of resources for every stage of the development pathway to facilitate and advance infectious disease research. These include repositories, genomics and bioinformatics services and tools, preclinical studies, and clinical trials. You may request services if you are an investigator in academia, a not-for-profit organization, industry, or government in the United States or worldwide. You need not be a grantee of NIAID or another National Institutes of Health Institute or Center. Look to each resource for further eligibility information.

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out Support for Infectious Disease Product Developers.


See a full list of resources for STI researchers

Meetings

Past Meetings

Current Challenges in Evaluating Antimicrobials for Urogenital Gonorrhea
Experts Collaborate to Design Thorough and Effective Future Trials
February 5-6, 2019

Malaria Information for Researchers

NIAID is the lead agency in the U.S. federal government supporting malaria research and development. The Institute has a longstanding commitment to malaria research to support the goals of reducing morbidity and mortality from malaria and ultimately eradicating the disease. NIAID is conducting and supporting research to better understand the disease, develop effective alternatives to mosquito control, and create diagnostics, treatments, and a vaccine to prevent infection.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Support for Research

Funding Opportunities

Contact the Parasitology and International Programs Branch (PIPB) within the Division of Microbiology and Infectious Diseases to learn about possible funding opportunities.


Search all NIAID funding opportunities and announcements

Connect with Other Researchers

Search for scientists at NIAID who research malaria in the scientist directory.

Search for scientists funded by NIAID who research malaria on RePORTER.

 

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. Look to each resource for eligibility information. See all resources for malaria researchers

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out NIAID's support for infectious disease product developers.

Programs & Networks

NIAID encourages partnerships among other agencies and foundations, private industry, federal and local government and other organizations with similar goals to help build and sustain research infrastructure and to translate and implement research findings as public health practices.

For example, the NIAID-funded International Centers of Excellence for Malaria Research are a global network of centers in malaria-endemic areas conducting multidisciplinary research on the parasite, mosquito vector, and human host factors responsible for malaria.


Read more about NIAID-supported programs and networks that further malaria research

Tickborne Diseases Information for Researchers

NIAID is conducting and supporting research to find better ways to diagnose, treat, and prevent tickborne diseases (TBD) as well as ways to control the tick populations that transmit microbes.

Support for Research

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. See all resources for tickborne disease researchers

For researchers developing products such as diagnostics, vaccines, or drug therapies, NIAID provides repositories, genomics and bioinformatics services and tools, preclinical studies, and clinical evaluation that support each stage of the product development pathway. Read more about NIAID's support for infectious disease product developers.

Funding Opportunities

Contact the following staff within the Division of Microbiology and Infectious Diseases to learn about possible funding opportunities:

  • Dr. Sam Perdue, Chief, Basic Sciences Section, Rickettsial and Related Diseases Program Officer, Bacteriology and Mycology Branch
  • Dr. Nadine Bowden, Lyme Disease Program Officer, Bacteriology and Mycology Branch
  • Dr. Adriana Costero-Saint Denis, Program Officer, Vector Biology, Parasitology and International Programs Branch

Search all funding opportunities and announcements

Connect with Other Researchers

Lyme Disease Information for Researchers

NIAID has a long-standing commitment to conduct research on Lyme disease. The major goals of the NIAID Lyme disease research program are to develop better means of diagnosing, treating, and preventing this disease. To accomplish these objectives, the NIAID Lyme disease research portfolio includes a broad range of activities designed to increase our understanding of this disease.

Support for Research

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services developed in its labs to the general scientific community for the advancement of biomedical research.


Read more about tools and resources available to researchers that further the advancement of Lyme disease research

Connect with Other Researchers

Search for scientists at NIAID who research lyme disease in the scientist directory.

Search for scientists funded by NIAID who research lyme disease on RePORTER.
 

Research on Tickborne Diseases

NIAID offers resources, information about funding, and ways to connect to other scientists researching tickborne diseases including lyme disease.


Read more information for researchers of tickborne diseases

HIV/AIDS Information for Researchers

NIAID-supported investigators are conducting a wide range of research on all areas of HIV/AIDS, including developing and testing preventive HIV vaccines, prevention strategies, and new treatments for HIV and associated coinfections, co-morbidities, and complications.  Through laboratories and clinics on the NIH campus in Bethesda, MD, and a vast network of research supported at universities, medical centers, and clinical trial sites around the globe, NIAID is working to better understand HIV and how it causes disease, find new tools to prevent HIV infection including a preventive vaccine, develop new and more effective treatments for people living with HIV, and hopefully, find a cure.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Scientific Support

Funding Opportunities

NIAID is funding research on HIV/AIDS, including developing and testing preventive HIV vaccines, prevention strategies, and new treatments for HIV infection and associated coinfections, co-morbidities, and complications.


See a full list of HIV/AIDS related funding opportunities

Resources for Researchers

NIAID offers resources such as technology for licensing or collaboration, computer applications, and other tools and services developed in its labs to the general scientific community for the advancement of biomedical research.


Read more about tools and resources available to researchers that further the advancement of HIV/AIDS research

Programs & Networks

NIAID encourages partnerships among other agencies and foundations, private industry, federal and local government and other organizations with similar goals to help build and sustain research infrastructure and to translate and implement research findings as public health practices.

Such partnerships ensure that the research will lead to findings that are ultimately feasible and meaningful for impacted communities. NIAID is deeply committed to local and international research collaboration that are mutually beneficial and scientifically productive.


Read more about NIAID-supported collaborations and partnerships that further HIV/AIDS research

Related NIH Programs

For decades NIAID had supported the separate Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) cohort studies. MACS was a study of gay and bisexual men, while WIHS was a study of women who had other risk factors for HIV.

In 2019, the National Heart, Lung, and Blood Institute (NHLBI) became the primary steward of the new MACS/WIHS-CSS. For this effort, the NHLBI is working in close collaboration with the NIH Office of AIDS Research (OAR) as well as several co-funding institutes across the NIH.


Read more about the MACS/WIHS on the NHLBI site

Connect with NIAID Researchers

Food Allergy Information for Researchers

Since 2003, NIAID has substantially increased its support for food allergy research, from basic research in allergy and immunology to epidemiological and observational studies to identify risk factors and clinical trials that are testing new strategies to prevent and treat food allergy.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services developed in its labs to the general scientific community for the advancement of biomedical research.


Read more about tools and resources available to researchers that further the advancement of food allergy research

Connect With Other Researchers

Search for scientists at NIAID who research food allergy in the scientist directory.

Search for scientists funded by NIAID who research food allergy on RePORTER. 

 

Programs & Networks

NIAID supports a spectrum of research, from basic studies in allergy and immunology to food allergy clinical trials. Through these efforts, NIAID-funded scientists and clinicians are making significant progress in combating food allergies that affect millions of children and adults worldwide.


Read more about food allergy research programs funded by NIAID

Eczema (Atopic Dermatitis) Information for Researchers

NIAID conducts and supports basic research in allergy and immunology that increases our understanding of the immune system and how it contributes to the development of atopic dermatitis and its complications. NIAID also funds patient-centered research to explore the genetic determinants of eczema and to evaluate new strategies to prevent and treat the disease.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Support for Research

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services developed in its labs to the general scientific community for the advancement of biomedical research.


Find resources that support and further the researchers of allergic diseases

Connect with Other Researchers

Search for scientists at NIAID who research eczema in the scientist directory.

Search for scientists funded by NIAID who research eczema on RePORTER.

 

 

 

Programs & Networks

Atopic Dermatitis Research Network scientists aim to understand immune system responses in the skin by comparing responses to viral and bacterial skin infections in healthy individuals with those in people with atopic dermatitis.

Ebola and Marburg Information for Researchers

NIAID is conducting and supporting research to find new and improved ways to diagnose, treat, and prevent Ebola and Marburg infections. Through the information offered here, the Ebola and Marburg scientific community can learn about NIAID funding opportunities, programs, and networks to further research and encourage collaboration. This section also provides information on resources provided by NIAID to advance product development.

Support for Research

Funding

NIAID is always accepting researcher-initiated applications. Connect with one of the NIAID program officers working in your area of research listed below about potential or related funding for Ebola virus and Marburg virus research.

Virology Branch

Office of Biodefense, Research Resources and Translational Research


Search all NIAID funding opportunities and announcements

Programs & Networks

  • The NIAID-funded Centers of Excellence for Translational Research program is funding innovative research to develop novel therapeutics and vaccines against Ebola and Marburg viruses. Filovirus research is also supported through the National Biocontainment Research Facilities.
  • NIAID funds the Centers for Research in Emerging Infectious Diseases (CREID), a global network of multidisciplinary investigations into how and where viruses and other pathogens can emerge from wildlife and spillover to cause disease in people. Research is led by 10 Centers and one Coordinating Center and involves collaborations with peer institutions in the United States and 28 other countries. 

See a full list of Ebola and Marburg programs and networks funded by NIAID

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. See all resources for Ebola and Marburg researchers.

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out NIAID's support for infectious disease product developers.

Connect With Other Researchers

Search for scientists at NIAID who research ebola and marburg in the scientist directory. The Integrated Research Facility also does research on Ebola and Marburg.

Search for scientists funded by NIAID who research malaria on RePORTER.

Coronaviruses Information for Researchers

NIAID provides research funding and resources for the scientific community to facilitate the development of vaccines, therapeutics, and diagnostics for infectious diseases, including those caused by coronaviruses.

Support for Research

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. See all resources for coronavirus researchers

For researchers developing products such as diagnostics, vaccines, or drug therapies, NIAID provides repositories, genomics and bioinformatics services and tools, preclinical studies, and clinical evaluation that support each stage of the product development pathway. Read more about NIAID's support for infectious disease product developers.

Also, visit the NIH COVID-19 website for additional resources from other NIH Institutes and Centers.

Funding Information

  • To find grant funding opportunities specific to COVID-19, search for COVID on our Opportunities page.
  • You may consider other funding opportunities that allow you to propose COVID-19 research, for example, Parent Program Announcements.
  • To find all NIAID contract funding opportunities, see contract solicitations.

For the latest information, read recent NIAID Funding News articles.

You can also check out special announcements that will keep you up-to-date on other NIAID-relevant NIH Guide notices.

Data Sharing

Request Access to NIAID COVID-19 Clinical Trials Data Sets

AccessClinicalData@NIAID is an NIAID cloud-based, secure data platform that enables sharing of and access to data sets from NIAID COVID-19 clinical trials for the basic and clinical research community. Read more about AccessClinicalData@NIAID.

Other Opportunities for Shared Data

The Seattle Structural Genomics Center for Infectious Diseases and Center for Structural Genomics of Infectious Diseases are making their data publicly available. See more information about the Centers for Research on Structural Biology of Infectious Diseases (CRSTAL-ID) in general.

Connect With Other Researchers

The COVID-19 Scientific Interest Group was created to promote collaboration and facilitate the exchange of information and resources among NIH intramural scientists and their HHS colleagues concerning research on COVID-19 and SARS-CoV-2.

Search for scientists at NIAID who research coronaviruses in the scientist directory.

Search for scientists funded by NIAID who research coronaviruses on RePORTER.

Biosafety Information

NIH currently recommends that laboratories working with SARS-CoV-2 adhere to the Centers for Disease Control and Prevention (CDC) interim laboratory biosafety guidelines for collecting and handling specimens potentially containing SARS-CoV-2. In addition, all research subject to the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines) must be reviewed and approved by an Institutional Biosafety Committee (IBC).

Get additional information about the NIH Guidelines and IBCs.

Questions related to the NIH Guidelines may be addressed to NIHGuidelines@od.nih.gov

Immune Response to COVID-19

NIAID researchers are spearheading a large, international collaboration to investigate the innate and adaptive immune responses during acute COVID-19 infection and convalescence. The overall goal is to identify immunological and virological correlates and predictors of clinical outcomes. Researchers are currently seeking physicians to collaborate.


Read more about immune response to COVID-19 research

Seher H. Anjum, M.D.

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Translational Mycology Section
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Program Description

Associate Investigator for Protocol 93-I-0106: Cryptococcosis in Previously Healthy Adults

Background: 

Cryptococcus is a fungus that causes infections most commonly in immunocompromised patients, such as those with AIDS and solid organ transplant recipients and is currently responsible for an estimated 15% of all AIDS-related deaths globally. Within the U.S., approximately 15-20% have no identifiable immune defect and cryptococcal infection in these hosts has a mortality rate of 30-50% despite optimal antifungal therapy.  

The objectives of this protocol can be broadly categorized as: 

  • Characterize the immunologic and genetic mechanisms predisposing to disease acquisition.
  • Understand the post-infectious inflammatory response and distinguish its consequences from those directly due to fungal growth.
  • Management of post-infectious neuro-inflammatory syndromes associated with cryptococcal meningitis 

This protocol recruits patients who have microbiological evidence of cryptococcal neurologic or non-CNS disease (typically pulmonary or bone). Cerebrospinal fluid (CSF) and blood samples collected during clinical care, are used to measure serum and intrathecal cellular and soluble cytokines as well as to perform in-situ immunohistochemistry. Observational data detailing audiological, ophthalmological and neurocognitive deficits in these patients is also recorded. 

We have recently described a post-infectious inflammatory syndrome (PIIRS) associated with cryptococcal meningoencephalitis (CM) which can be best described as a neuro-inflammatory state during which CM patients present with altered mental status (Montreal Cognitive Assessment Score <22/30), auditory deficits and/or vision loss despite having negative CSF fungal cultures after being treated with optimal antifungal therapy. Based on findings in CSF and brain tissue samples, the underlying mechanism behind this phenomenon is related to the intrathecal expansion of both the innate and adaptive immune system, including HLA-DR+ CD4+ and CD8+ lymphocytes and NK cells. In a cohort of 15 previously healthy CM patients, we have been able to demonstrate an improvement in clinical outcomes with pulse corticosteroid therapy for patients with PIIRS and are currently exploring alternative immunomodulatory agents as steroid-sparing therapy for this indication.

Selected Publications

Okeagu CU, Anjum SH, Vitale S, Wang J, Singh D, Rosen LB, Magone MT, Fitzgibbon EJ, Williamson PR. Ocular Findings of Cryptococcal Meningitis in Previously Health Adults. J Neuroophthalmol. 2022 Oct 18.

Anjum S, Dean O, Kosa P, Magone MT, King KA, Fitzgibbon E, Kim HJ, Zalewski C, Murphy E, Billioux BJ, Chisholm J, Brewer CC, Krieger C, Elsegeiny W, Scott TL, Wang J, Hunsberger S, Bennett JE, Nath A, Marr KA, Bielekova B, Wendler D, Hammoud DA, Williamson P. Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients Treated With Pulse Taper Corticosteroids for Post-infectious Inflammatory Syndrome. Clin Infect Dis. 2021 Nov 2;73(9):e2789-e2798.

Yang DH, England MR, Salvator H, Anjum S, Park YD, Marr KA, Chu LA, Govender NP, Lockhart SR, Desnos-Ollivier M, Chen S, Halliday C, Kan A, Chen J, Wollenberg KR, Zelazny A, Perfect JR, Chang YC, Bennett JE, Holland SM, Meyer W, Williamson PR, Kwon-Chung KJ. Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection. mBio. 2021 Oct 26;12(5):e0270821.

Anjum S, Williamson PR. Clinical Aspects of Immune Damage in Cryptococcosis. Curr Fungal Infect Rep. 2019 Sep;13(3):99-108.

Visit PubMed for a complete publication listing.

Additional Information

Research Networks

CINCH (Cryptococcus Infection Network in non-HIV Cohort)

Training Programs

NIH-Duke Clinical Research Training Program

 

Major Areas of Research
  • Cryptococcal meningitis in previously healthy hosts
  • Post-infectious neuro-inflammatory responses 
  • The use of steroid-sparing, immunomodulatory agents in neuro-inflammation