Brenchley Research Group

Jason Brenchley, Ph.D. (He/Him/His)

Specialty(s): Pathology, Medical Microbiology

Education:

M.S., 1999, Idaho State University

Ph.D., 2003, University of Texas Southwestern Medical Center at Dallas

Dr. Brenchley received a master’s degree from Idaho State University in 1999 and received a Ph.D. from the University of Texas Southwestern Medical Center at Dallas in 2003. He joined NIH as a research fellow, studying immunopathogenesis and mucosal immunology in HIV-infected individuals. Since 2008, he has become an investigator in the Laboratory of Molecular Microbiology and has been a senior investigator since 2013.

Kelsie L. Brooks, Ph.D. (She/Her/Hers)

Education:

Ph.D., Emory University
B.S., Oklahoma University

I am investigating SARS-CoV-2 infections in human samples and non-human primate models, particularly exploring gastrointestinal pathology and inflammation. Additionally, I have examined impacts of SARS-CoV-2 infections on the gut microbiome.

Fabiola Marie Castello Casta, B.S. (She/Her/Hers)

Education:

B.S., Universidad de Puerto Rico, Cayey

Languages Spoken: Spanish

Jacob Flynn, B.S. (He/Him/His)

Education:

B.S., Cornell University

My research aims to understand bacterial-mediated mechanisms underlying microbial translocation in progressively SIV-infected Asian macaques. We’ve found that the bacteria that translocate are a subset of the total bacterial microbiome, and that these translocating taxa have unique functional properties that can be chemically inhibited.

Alexandra M. Ortiz O’Sick, Ph.D. (She/Her/Hers)

Education:

Ph.D., University of Pennsylvania

BA, University of Virginia

Languages Spoken: Spanish

My research is focused on investigating the intersection between the microbiome, immunity, and disease in non-human primate models and hosts of SIV for the purposes of understanding disease mechanisms in people living with HIV.

Andrew Rahmberg, Ph.D. (He/Him/His)

Education:

Ph.D., Harvard University
B.S., Boston University

My work explores the mechanisms by which natural hosts for SIV have co-evolved with SIV to avoid disease progression.

Jennifer Simpson, Ph.D. (She/Her/Hers)

Education:

Ph.D., University of Queensland, Australia
B.S., University of Queensland, Australia

My research focus is evaluating the physiological role and clonotypic structure of antigen specific CD8+ T cells in multiple anatomical sites during SIV infection in nonhuman primates.

Debra Yee, B.S. (She/Her/Hers)

Education:

B.S., University of Maryland

I am exploring the pathogenesis of emerging viral infections in old world nonhuman primates. These studies will determine the appropriateness of NHPs as a model of human viral infections which will help in the development of antiviral and vaccine development for emerging RNA viral infections.