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Laboratory of Viral Diseases

Bernard Moss, M.D., Ph.D., Chief

The Laboratory of Viral Diseases carries out investigations on the molecular biology of viruses, the interactions of viruses with host cells, the pathogenesis of viral diseases, and host defense mechanisms. The studies are designed to increase fundamental knowledge as well as to facilitate the development of new approaches to the prevention and treatment of disease. The laboratory is well equipped with an electron microscope, confocal microscopes, FACS machines, DNA sequencers, PCR machines, ultracentrifuges, and other standard items. The members of the laboratory are interactive and hold weekly seminars in which current research is presented and discussed.

Major Areas of Research

  • Viral entry into cells
  • Regulation of gene expression
  • Mechanisms of DNA replication
  • Assembly and transport of viral proteins and particles
  • Actions of viral growth factors and immune defense molecules
  • Determinants of viral virulence
  • Viral targets of humoral and cellular immunity
  • Development of recombinant expression vectors, candidate vaccines, and antiviral agents
  • Wide range of DNA and RNA viruses including HIV, poxviruses, herpesviruses, papillomaviruses, influenza virus, and flaviviruses
Content last reviewed on December 8, 2016