Lisco Research Group

Primary and acquired immunodeficiencies like HIV/AIDS are associated with high prevalence of skin and mucosal diseases caused by Human Papillomaviruses (HPV) as well as an accelerated progression to HPV-related cancers. Dr. Lisco`s primary focus is on delineating the genetic, immunological, and molecular determinants of persistence, regression, or progression of HPV-related diseases to inform innovative preventive and therapeutic strategies. The translational workflow of the laboratory is based on the integration of clinical protocols focused on the identification of clinical and epidemiological predictors of severe HPV-related diseases with studies on host genetics and tissue-specific immunopathogenesis at the skin and mucosal barriers eventually informing personalized interventional clinical protocols.