Major Areas of Research
- Definition of epidemiologic features of HIV-1 and HIV-2 infections in developing countries and the United States
- Assessment of biomedical interventions to control HIV, including circumcision, prevention of mother-to-child transmission, pre-exposure prophylaxis, and vaccine development
- Study of the serologic responses to SARS-CoV-2 and other coronaviruses to aid in the defining the epidemiologic features and clinical responses to COVID-19 in US and Africa
- Quantification of the latent HIV reservoir in virally suppressed Ugandan men and women with identification of immunologic predictors of the reservoir size
HIV/AIDS is a global pandemic with 37 million individuals living with HIV infection worldwide. Approximately 2.1 million people become infected each year, and over 39 million people have already died as a result of HIV-related diseases. Although an estimated one million people are HIV infected in the U.S., the vast majority of HIV-infected individuals reside in developing countries. HIV infection continues to spread rapidly among heterosexuals and perinatally throughout Africa, Latin America, and Asia. Since the beginning of this project, the International HIV/STD Laboratory of the LIR has instituted international collaborations in 28 countries. The objectives of this lab are: 1) To define the unique epidemiologic, clinical, virologic, and immunologic features of HIV-1 infection and co-infections in developing countries; 2) To examine the viral kinetics and other biological and behavioral factors associated with HIV-1 transmission; 3) To characterize the molecular strains of HIV-1 by region for infectiousness, transmission, and immunologic response including the role of HIV superinfection; 4) To develop and evaluate novel interventions to prevent HIV transmission, including microbicides, circumcision and vaccines; 5) To examine the efficacy of antiretroviral drugs in preventing transmission and increasing survival in developing countries; 6) To examine the effects of HIV+ to HIV+ solid organ transplantation of patient health, HIV disease, and immunological make-up.
Dr. Quinn obtained his M.D. from Northwestern University. He was a research associate in infectious diseases in the NIAID Laboratory of Parasitic Diseases and completed a fellowship in infectious diseases at the University of Washington. He returned to NIAID and later became chief of the Section on International HIV/STI Research. In 2006, he was appointed as associate director for International Research in the Division of Intramural Research. Since 1981, he has been assigned to the division of infectious diseases at Johns Hopkins University, where he became a professor of medicine in 1991, and in 2006 became director of the Center for Global Health. Dr. Quinn is a member of the National Academy of Medicine in the National Academies of Science and is a fellow of the American Association for the Advancement of Science and the Association of American Physicians.
AOA Epidemiology Research Award; Charles C. Shepard Science Award; James H. Nakano Citation for Outstanding Scientific Publication; USPHS Outstanding Service Award; USPHS Meritorious Service Award; USPHS Distinguished Service Award; Thomas Parran Lifetime Achievement Award; Distinguished Leader in Global Health Award of CUGH.
- American Association for the Advancement of Science
- Association of American Physicians
- American College of Physicians
- American Society for Microbiology
- American Society for Tropical Medicine and Hygiene
- American Federation for Clinical Research
- American Society for Clinical Investigation
- American Sexually Transmitted Diseases Association
- Infectious Disease Society of America
- AIDS Research and Human Retroviruses
- Infectious Diseases in Clinical Practice
- Journal of AIDS
- Journal of Clinical Investigation
- The Journal of Infectious Diseases
- Sexually Transmitted Diseases
- Scientific Advisory Committee, HIV Vaccine Trials Network
- Scientific Advisory Committee, HIV Prevention Trials Network
- Scientific Steering Committee for Targeted Evaluations/Operations Research, Office of the U.S. Global AIDS Coordinator
- Chair, National Academy of Medicine Board of Global Health
- Member, IDSA Diagnostics Policy Task Force
- Advisor, MacArthur Fellows program
- Advisor, Global Health Interest Group of NIH
- Chair, Committee on Global Health, Infectious Diseases Society of America
Oliver Laeyendecker, M.S., M.B.A., Ph.D.
Steven J. Reynolds, M.D., M.P.H.
Andrew Redd, Ph.D.
Anna Lauren Eisenberg
Briana A. Lynch
Alyssa R. Martin, Ph.D.
Jessica Lynn Prodger, Ph.D.
Aaron A. Tobain, M.D., Ph.D.
Ron Gray, M.D.
Maria Wawer, M.D.
David Serwadda, M.B., Ch.B., M.Med., M.P.H.
Nelson K. Sewankambo, M.B., Ch.B, M.Med., M.Sc., F.R.C.P., L.L.D.
Lawrence W. Chang, M.D., M.P.H.
Mary Kate Grabowski, Ph.D.
Charlotte A. Gaydos, Dr.P.H.
Sheila West, Ph.D.
Prodger JL, Lai J, Reynolds SJ, Keruly JC, Moore RD, Kasule J, Kityamuweesi T, Buule P, Serwadda D, Nason M, Capoferri AA, Porcella SF, Siliciano RF, Redd AD, Siliciano JD, Quinn TC. Reduced Frequency of Cells Latently Infected with Replication-Competent HIV-1 in Virally Suppressed Individuals Living in Rakai, Uganda.Clin Infect Dis. 2017 May.
Reynolds SJ, Ssempijja V, Galiwango R, Ndyanabo A, Nakigozi G, Lyagoba F, Nazziwa J, Redd A, Lamers SL, Gray R, Wawer M, Serwadda D, Quinn TC. Low Rates of Transmitted Drug Resistance Among Newly Identified HIV-1 Seroconverters in Rural Rakai, Uganda. AIDS Res Hum Retroviruses. 2017 May;33(5):448-451.
Kong X, Kigozi G, Ssekasanvu J, Nalugoda F, Nakigozi G, Ndyanabo A, Lutalo T, Reynolds SJ, Ssekubugu R, Kagaayi J, Bugos E, Chang LW, Nanlesta P, Mary G, Berman A, Quinn TC, Serwadda D, Wawer MJ, Gray RH. Association of Medical Male Circumcision and Antiretroviral Therapy Scale-up With Community HIV Incidence in Rakai, Uganda. JAMA. 2016 July;316(2):182-90.
Grabowski MK, Kong X, Gray RH, Serwadda D, Kigozi G, Gravitt PE, Nalugoda F, Reynolds SJ, Wawer MJ, Redd AD, Watya S, Quinn TC, Tobian AA. Partner Human Papillomavirus Viral Load and Incident Human Papillomavirus Detection in Heterosexual Couples. J Infect Dis. 2016 Mar;213(6):948-56.
Quinn TC, Gaydos CA. Treatment for Chlamydia Infection--Doxycycline versus Azithromycin. N Engl J Med. 2015 Dec;373(26):2573-5.