Chen-Feng Qi, M.D., Ph.D.

Pathology Core

Rockville, MD

Chen-Feng Qi, M.D., Ph.D.

Chief, Pathology Core

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Chen-Feng Qi, M.D., Ph.D.

Major Areas of Research

  • Pathological studies of human disease using animal models.

Program Description

Provides focused support for the overall mission and goals of the LIG. It offers up-to-date expert support to NIAID intramural, as well as non-NIAID investigators, providing any and all research pathology related services. These include preparation, diagnostics and reports for research pathology samples. Services also include collaborative advice in the experimental design, conduct and data interpretation for studies involving laboratory animals as well as pathological validation of findings for research projects.

Performs immunopathological, histopathology experiments, and data collection, analysis, and evaluation for collaborate research projects.



M.D., Ph.D., 1990, Gifu University School of Medicine, Nagoya, Japan

Dr. Qi received her medical degree and worked as a pathologist in China and was then awarded her Ph.D./M.D. from the department of pathology at Gifu University School of Medicine, Nagoya, Japan in 1990. In 1993, following three years of postdoctoral training in the Laboratory of Tumor Immunology and Biology, National Cancer Institute, at the National Institutes of Health, Dr. Qi was appointed research assistant professor in the V.T. Lombardi Cancer Research Center, Georgetown University School of Medicine. In 1995, she joined the NIAID Laboratory of Immunopathology as a senior staff fellow/senior pathology research specialist and was also appointed laboratory manager.

In 2013, she became the chief of the Pathology Core in the Laboratory of Immunogenetics (LIG). As a well-trained and highly experienced pathologist, Dr. Qi is an accomplished research scientist who is actively involved in training LIG staff in histoimmunological and pathological technologies, in addition to carrying out her own original research and collaborations.

Selected Publications

Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R, Su XZ. Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E511-20.

Qi CF, Zhang R, Sun J, Li Z, Shin DM, Wang H, Kovalchuk AL, Sakai T, Xiong H, Kon N, Gu W, Morse HC 3rd. Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC. Leuk Res. 2013 Dec;37(12):1680-9.

Qi CF, Kim YS, Xiang S, Abdullaev Z, Torrey TA, Janz S, Kovalchuk AL, Sun J, Chen D, Cho WC, Gu W, Morse HC 3rd.Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms. Int J Mol Sci. 2012;13(5):6204-19.

Qi CF, Shin DM, Li Z, Wang H, Feng J, Hartley JW, Fredrickson TN, Kovalchuk AL, Morse HC 3rd. Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice. J Pathol. 2010 May;221(1):106-16.

Qi CF, Li Z, Raffeld M, Wang H, Kovalchuk AL, Morse HC 3rd. Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments. Immunol Res. 2009;45(1):62-74.

Qi CF, Zhou JX, Lee CH, Naghashfar Z, Xiang S, Kovalchuk AL, Fredrickson TN, Hartley JW, Roopenian DC, Davidson WF, Janz S, Morse HC 3rd. Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer Res. 2007 Mar 15;67(6):2439-47.

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