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Laboratory of Immunogenetics

Susan K. Pierce, Ph.D., Chief

The research in the Laboratory of Immunogenetics (LIG) focuses on the cellular and molecular mechanisms that underlie the signaling functions of immune cell receptors. This work encompasses a wide spectrum of experimental approaches from the structural determination of immune receptors to live-cell image analysis of the behavior of chemotactic receptors.​

LIG members are highly interactive, creating a unique environment in which structural biology, molecular, and cell biology are interfaced. Interactions within LIG are facilitated by weekly work-in-progress presentations detailing recent advances and future directions of LIG fellows and students.

Research Objectives

  • Structure and function of the natural killer (NK) cell inhibitory and activating receptors
  • Molecular mechanisms underlying the functions of the FcgammaRIIB receptor
  • Signal transduction pathway in chemotaxis mediated by G protein-coupled receptors
  • Function of the B-cell antigen receptor in initiating signaling cascades and transporting antigen for processing with the MHC class II molecules
  • Structures of components of important pathogens and the cellular receptors with which they interact

Content last reviewed on September 13, 2013