Dr. Brzostowski received his B.A. from Rutgers College in 1990 and his Ph.D. in 1998 from the University of Virginia. As a postdoctoral fellow at the National Institute of Diabetes, Digestive and Kidney Diseases, he used live cell imaging technologies to study the mechanisms that regulate directional cell movement in the model organism Dictyostelium discoideum. Dr. Brzostowski was recruited to LIG in 2005 to establish a core imaging facility that would provide principal investigators, fellows, and students the ability to carry out sophisticated live cell imaging experiments with cutting-edge technologies. Dr. Brzostowski is foremost a teacher, training those who use his facility the fundamentals of microscopy to eventually become masters themselves in modern imaging modalities. In addition to his duties at LIG, Dr. Brzostowski is a faculty member of the summer Physiology Course at the Marine Biological Laboratory at Woods Hole, Massachusetts, he has taught a variety of international microscopy courses and teaches locally at the FAES.
Sherling ES, Knuepfer E, Brzostowski JA, Miller LH, Blackman MJ, van Ooij C. The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. Elife. 2017 Mar 2;6.
Lee J, Sengupta P, Brzostowski J, Lippincott-Schwartz J, Pierce SK. The nanoscale spatial organization of B-cell receptors on immunoglobulin M- and G-expressing human B-cells. Mol Biol Cell. 2017 Feb 15;28(4):511-523.
Cao X, Yan J, Shu S, Brzostowski JA, Jin T. Arrestins function in cAR1 GPCR-mediated signaling and cAR1 internalization in the development of Dictyostelium discoideum. Mol Biol Cell. 2014 Oct 15;25(20):3210-21.
Xu L, Li G, Wang J, Fan Y, Wan Z, Zhang S, Shaheen S, Li J, Wang L, Yue C, Zhao Y, Wang F, Brzostowski J, Chen YH, Zheng W, Liu W. Through an ITIM-independent mechanism the FcγRIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19. J Immunol. 2014 Jun 1;192(11):5179-91.
Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR. Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay. J Cell Sci. 2013 Oct 15;126(Pt 20):4614-26.
Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T. A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis. Dev Cell. 2012 Jan 17; 22(1):92-103.