Joseph Brzostowski, Ph.D.

Joseph Brzostowski, Ph.D.

Credit: NIAID
Chief, Twinbrook Imaging Facility, Rockville
Senior Associate Scientist, Laboratory of Immunogenetics

Biography

Dr. Brzostowski received his B.A. from Rutgers College and his Ph.D. from the University of Virginia. As a postdoctoral fellow at the National Institute of Diabetes, Digestive and Kidney Diseases, Dr. Brzostowski used live cell imaging technologies to study the mechanisms that regulate directional cell movement in the model organism Dictyostelium discoideum. Dr. Brzostowski was recruited to LIG in 2005 to establish a core imaging facility that would provide principal investigators, students, and fellows the ability to carry out sophisticated live cell imaging experiments with cutting-edge technologies. As core chief, Dr. Brzostowski actively trains LIG staff and outside collaborators to master a variety of imaging modalities. In addition to his duties at LIG, Dr. Brzostowski is a managing faculty member of the summer Physiology Course at the Marine Biological Laboratory at Woods Hole, Massachusetts. 

See more about the LIG Imaging Facility.

Selected Publications

Connelly SV, Manzella-Lapeira J, Levine ZC, Brzostowski J, Krymskaya L, Rahman RS, Ellis AC, Amin SN, Sá JM, Wellems TE. Restructured Mitochondrial-Nuclear Interaction in Plasmodium falciparum Dormancy and Persister Survival after Artemisinin Exposure. mBio. 2021 Jun;12(3):e0075321. 

Ahmad M, Manzella-Lapeira J, Saggu G, Ito D, Brzostowski JA, Desai SA. Live-Cell FRET Reveals that Malaria Nutrient Channel Proteins CLAG3 and RhopH2 Remain Associated throughout Their Tortuous Trafficking. mBio. 2020 Sep;11(5):e01354-20. 

Ambegaonkar AA, Kwak K, Sohn H, Manzella-Lapeira J, Brzostowski J, Pierce SK. Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens. Sci Adv. 2020 Jul;6(30):eaba6493. 

Low LM, Azasi Y, Sherling ES, Garten M, Zimmerberg J, Tsuboi T, Brzostowski J, Mu J, Blackman MJ, Miller LH. Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake. mBio. 2019 Jul;10(4):e01460-19. 

Akkaya B, Roesler AS, Miozzo P, Theall BP, Al Souz J, Smelkinson MG, Kabat J, Traba J, Sack MN, Brzostowski JA, Pena M, Dorward DW, Pierce SK, Akkaya M. Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation. J Immunol. 2018 Dec;201(11):3294-3306. 

Kwak K, Quizon N, Sohn H, Saniee A, Manzella-Lapeira J, Holla P, Brzostowski J, Lu J, Xie H, Xu C, Spillane KM, Tolar P, Pierce SK. Intrinsic properties of human germinal center B cells set antigen affinity thresholds. Sci Immunol. 2018 Nov;3(29):eaau6598.

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