Joseph Brzostowski, Ph.D.

Joseph Brzostowski, Ph.D.

Credit: NIAID
Chief, Twinbrook Imaging Facility, Rockville
Senior Associate Scientist, Laboratory of Immunogenetics


Dr. Brzostowski received his B.A. from Rutgers College in 1990 and his Ph.D. in 1998 from the University of Virginia. As a postdoctoral fellow at the National Institute of Diabetes, Digestive and Kidney Diseases, Dr. Brzostowski used live cell imaging technologies to study the mechanisms that regulate directional cell movement in the model organism Dictyostelium discoideum.Dr. Brzostowski was recruited to LIG in 2005 to establish a core imaging facility that would provide principal investigators, students, and fellows the ability to carry out sophisticated live cell imaging experiments with cutting-edge technologies. As core chief, Dr. Brzostowski actively trains LIG staff to master a variety of imaging modalities. He is also an accomplished research scientist who carries out his own research and collaborations. In addition to his duties at LIG, Dr. Brzostowski is a faculty member of the summer Physiology Course at the Marine Biological Laboratory at Woods Hole, Massachusetts.

See more about the LIG Imaging Facility.

Selected Publications

Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR. Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relayJ Cell Sci. 2013 Oct 15;126(Pt 20):4614-26.

Martinez E, Brzostowski JA, Long EO, Gross CC. Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane. J Immunol. 2011 May 15;186(10):5538-42.

Xu X, Meckel T, Brzostowski JA, Yan J, Meier-Schellersheim M, Jin T. Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal. 2010 Sep 28;3(141):ra71.

Gross CC, Brzostowski JA, Liu D, Long EO. Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization. J Immunol. 2010 Sep 1;185(5):2918-26.

Brzostowski JA, Fey P, Yan J, Isik N, Jin T. The Elmo family forms an ancient group of actin-regulating proteins. Commun Integr Biol. 2009 Jul;2(4):337-40.

Isik N, Brzostowski JA, Jin T. An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev Cell. 2008 Oct;15(4):590-602.

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