Eric Long, Ph.D.

Molecular and Cellular Immunology Section

Established in 1988

Rockville, MD

Eric Long, Ph.D. (He/Him/His)

Chief, Molecular and Cellular Immunology Section

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Photo of Eric Long, Ph.D.

Major Areas of Research

  • Innate lymphocyte function in malaria
  • Fighting cancer with natural killer cells (NK): how to break tumor cell resistance
  • Regulation of NK cells by activating and inhibitory receptors

Program Description

The main interest of our lab has been the molecular basis of the regulation of human natural killer (NK) cell function in the context of different stimuli and the contribution of activating and inhibitory receptors to intracellular signals that dictate NK cell reactivity. NK cells are lymphocytes with important functions that include defense against viral and parasitic infections, elimination of tumor cells, regulation of adaptive immunity through cytotoxicity and cytokine secretion, and stimulation of vascular remodeling in early pregnancy. Fundamental knowledge on the regulation of natural killer cells can be applied to study their function in diseases such as cancer and malaria.

Severe malaria caused by Plasmodium falciparum parasite infection kills approximately 280,000 young children every year. Resistance to malaria is dependent on antibodies that are acquired after years of exposure. We have shown that NK cells destroy P. falciparum-infected red blood cells in the presence of antibodies from adults that have acquired clinical immunity to malaria. The antibody-dependent cellular cytotoxicity (ADCC) response of NK cells that we measured in peripheral blood samples obtained from people living in a region of high malaria transmission was associated with greater resistance to disease. A more detailed examination of the composition and function of NK cells in people exposed to intense malaria transmission is needed. See more about the NIAID Malaria Research Program and the MRP Collaborative Research Fellowship Award.

There has been remarkable progress in the application of basic discoveries in immunology to clinical care of cancer patients. Immunotherapy has successfully eliminated otherwise incurable cancers. Cytotoxic T cells and NK cells have been engineered to express chimeric antigen receptors (CAR) that selectively target tumor cells for elimination. However, the limited information currently available on signal transduction by CARs is a concern. Furthermore, a limitation of NK cells for CAR expression is their control by dominant inhibitory receptors for HLA class I. We are engineering NK-tailored CARs that can overcome this inhibition. A significant advantage of our approach is that CAR-NK cells would remain under physiological regulation by inhibitory receptors until they encounter a tumor cell.



Ph.D., University of Geneva, Switzerland

Dr. Long has a biochemistry degree from the ETH Zürich, and a Ph.D. in molecular biology from the University of Geneva, Switzerland. After postdoctoral research at the Carnegie Institution for Science and the National Cancer Institute, NIH, he returned to Geneva as a faculty member in the Department of Microbiology. There, he applied molecular approaches to isolate the first cDNA clones for MHC class II molecules. In 1983, he joined the Laboratory of Immunogenetics at the National Institute of Allergy and Infectious Diseases, NIH. While studying antigen presentation to CD4 T cells, he discovered new pathways for processing and MHC-II-restricted presentation of antigens from different cellular compartments. He became Senior Investigator and Head of the Molecular and Cellular Immunology Section in 1988.

In the mid-90’s, his main interest turned to the regulation of NK cell function, after his team identified molecular clones for a family of NK cell inhibitory receptors called KIR that engage MHC class I molecules on healthy cells to prevent killing by NK cells. The discovery of the signaling basis for inhibition by these receptors was selected as a "Pillar of Immunology" by the Journal of Immunology. His laboratory has uncovered fundamental properties of NK cell activation for cytotoxicity, which requires engagement of synergistic pairs of coactivation receptors, and how they could be exploited to design chimeric antigen receptors (CAR) tailored for NK-dependent lysis of tumor cells. As part of the Malaria Research Program at NIAID, his group showed that NK cells lyse red blood cells infected by Plasmodium falciparum in the presence of antibodies isolated from plasma of individuals that live in an area of high malaria transmission. Among such individuals, those with a higher abundance of specialized NK cells with stronger responsiveness to an antibody-binding Fc receptor had better odds of becoming resistant to malaria. His lab is interested in NK cell functionality in people chronically infected by Plasmodium falciparum and how NK cells protect them against malaria.

Selected Publications

Sim MJW, Stotz Z, Lu J, Brennan P, Long EO, Sun PD. T cells discriminate between groups C1 and C2 HLA-C. Elife. 2022 May 19;11:e75670. 

Anton OM, Peterson ME, Hollander MJ, Dorward DW, Arora G, Traba J, Rajagopalan S, Snapp EL, Garcia KC, Waldmann TA, Long EO. Trans-endocytosis of intact IL-15Ralpha–IL-15 complex from presenting cells into NK cells favors signaling for proliferationProc Natl Acad Sci. 2020 Jan 7; 117(1):522-531

Zhuang X, Long EO (2019) Inhibition-resistant CARs for NK cell cancer immunotherapyTrends Immunol.  2019 Dec;40(12):1078-1081.

Sim MJW, Rajagopalan S, Altmann DM, Boyton RJ, Sun PD, Long EO. Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-CProc Natl Acad Sci. 2019 Jun 25;116(26):12964-12973.

Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO. Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malariaJ Exp Med. 2019 Jun 3;216(6):1280-1290.

Zhuang X, Long EO CD28 homolog is a strong activator of natural killer cells for lysis of B7H7-positive tumor cellsCancer Immunol Res. 2019 Jun;7(6):939-951.

Visit PubMed for a complete publication listing.

Visit Google Scholar for a complete citation listing.

Research Group

Eric Long, Ph.D. & Research Group

Back row (L-R): Xiaoxuan Zhuang, Sumi Rajagopalan, Mary Peterson, Padmapriya Sekar. Front row (L-R): Malcolm Sim, Eric Long, Jingwen Jiang

Credit: NIAID
  • Sumati Rajagopalan, Ph.D., Staff Scientist
  • Kaveh Abdi, Biologist
  • Malcolm Sim, Postdoctoral Fellow
  • Xiaoxuan Zhuang, Postdoctoral Fellow
  • Padmapriya Sekar, Postdoctoral Fellow
  • James Woods, Post-baccalaureate Fellow
  • Paul Brennan, Post-baccalaureate Fellow


Eric Long is the new Director of the Malaria Research Program, Division of Intramural Research, NIAID - April 2022 

Geoff Hart’s paper in J Exp Med was one among ten chosen to be highlighted in the JEM Immunology Collection 2020—May 2020

The lab was ranked in the top 0.25% in immunology according to a standardized citation metrics database–August 2019

Xiaoxuan Zhuang has received an NIH Fellows Award for Research Excellence—2019

Geoff Hart’s paper in J Exp Med was one among ten chosen to be highlighted in the JEM Clinical Collection 2019—Summer 2019

Malcolm Sim’s paper in PNAS was accompanied by a Commentary article entitled “A natural killer cell receptor takes sharp aim at the world of bacteria.” —June 2019

Sumi Rajagopalan delivered the Keynote Address at the opening of the Annual Meeting of the American Society of Reproductive Immunology—June 2018

Press release:

Killer immune cells that halt malaria could hold key to new vaccines—June 2018

How to Apply

We are always interested in recruiting bright and motivated young scientists. If you think you fit the description, send us an application. Experience in imaging, cell biology, proteomics, and bioinformatics would be a plus.

Postdoctoral fellow

Submit in PDF format

  • Statement of interest (why you would like to work here)
  • Curriculum vitae and bibliography
  • Name and contact of three references

    Note: Do not attach letters of recommendation to your application.

Malaria Research Program Collaborative Research Fellowship

Fellowships will be awarded annually to a limited number of top applicants who aspire to improve our understanding of the biology, host-pathogen interactions, and transmission of malaria parasites.

See Malaria Research Program.

Research Networks

Malaria Research Program

Training Programs

NIH Postdoctoral Malaria Research Program Collaborative Fellowship

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