Xu Research Group

Dr. Xu’s group has a long-term interest in G protein-coupled receptors (GPCRs)’ signaling in chemotaxis of eukaryotic cell, metastasis of cancer cells, and viral infections, such as human immunodeficiency virus (HIV) infections and current COVID-19. Chemotaxis is directional cell migration guided by extracellular chemoattractant gradients. This cellular behavior of eukaryotic cells plays a critical role in many physiological processes, such as embryogenesis, neuron patterning, angiogenesis, innate immune responses to infections, metastasis of cancer cells, and the early development of the model organism Dictyostelium. Both Dictyostelium and neutrophil use G protein-coupled receptors (GPCRs), the largest groups of receptors in eukaryotic organisms that play pivotal roles in many processes closely related to human health and disease, to sense and move toward higher concentrations of extracellular chemoattractants. Applying state-of-art imaging technologies, Dr. Xu’s research proposed and identified locally recruited Ras inhibitors, C2GAP1 and CAPRI in Dictyostelium and human neutrophils, respectively, as essential players in GPCR-mediated Ras adaptation, gradient sensing, and cell sensitivity. Her discoveries suggest an evolutionarily conserved mechanism by which eukaryotic cells gate sensitive concentration ranges of chemoattractant for chemotaxis.

Xuehua Xu, Ph.D.

Senior Associate Scientist, Chemotaxis Signal Section

Contact: For contact information, search the NIH Enterprise Directory.

Specialty(s): Allergy and Immunology, Infectious Disease, Pathology, Medical Microbiology


Ph.D., Tsukuba University, Japan

B.S., M.S., Harbin Normal University, China

Dr. Xuehua Xu obtained her bachelor’s and master’s degrees in biology from Harbin Normal University, China, and her Ph.D. in biotechnology from Tsukuba University, Japan. In 2006, she was recruited as an assistant professor at the Georgetown University School of Medicine. In 2010, she was recruited to NIH as a staff scientist in Dr. Jin’s group. She was promoted to Associate Scientist in 2019 and Senior Scientist in 2021.

Learn more about Xuehua Xu, Ph.D.

Photo of Xuehua Xu, Ph.D.

HyunGee Ha, B.S.

IRTA fellow

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B.S., University of Maryland

Languages Spoken: Korean

PLCg2–mediated IP3 Dynamics in Neutrophil-Like HL60 Cells Using IP3 FRET Probe by Confocal Microscopy.

Learn more about HyunGee Ha, B.S.

Hyungee Ha, IRTA Fellow
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