Clinical Parasitology Section

Major Areas of Research

  • Clinical definition and pathogenesis underlying parasitic diseases
  • New methods of diagnosis of parasitic infections
  • Therapeutic interventions in parasitic infections
  • Hypereosinophilic syndromes (HES): from pathogenesis to novel therapeutic interventions

Program Description

The Clinical Parasitology Section is an interdisciplinary group of clinically trained LPD staff members who oversee the clinical research portfolio and provide clinical care, consultations, and training in tropical medicine and parasitology. The overriding goals of this program are

  • To gain insight into the clinical syndromes associated with parasitic infections
  • To understand and help define the pathogenesis underlying clinical disease
  • To identify better ways of treating individual infections and to prevent secondary consequences of treatment
  • To develop better diagnostic tools for the species-specific diagnosis of active parasitic infection

Although the Clinical Parasitology Section has protocols to see patients with any parasitic infection, the overwhelming majority of patients have neurocysticercosis, filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis), strongyloidiasis, hookworm infections, ascaraisis, giardiasis, echinococcosis, and leishmaniasis. We occasionally see patients with gnathostomiasis, African trypanosomiasis, Chagas disease, and malaria, among others.

Selected Publications

The Local Inflammatory Profile and Predictors of Treatment Success in Subarachnoid Neurocysticercosis. Harrison S, Thumm L, Nash TE, Nutman TB, O'Connell EM. Clin Infect Dis. 2021 May 4;72(9):e326-e333. doi: 10.1093/cid/ciaa1128. PMID: 33269789

Efficacy and Tolerability of Miltefosine in the Treatment of Cutaneous Leishmaniasis. Ware JM, O'Connell EM, Brown T, Wetzler L, Talaat KR, Nutman TB, Nash TE. Clin Infect Dis. 2021 Oct 5;73(7):e2457-e2562. doi: 10.1093/cid/ciaa1238. PMID: 33124666

A Randomized, Placebo-controlled, Double-blind Pilot Study of Single-dose Humanized Anti IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection. Legrand F, Herrick J, Makiya M, Ramanathan R, Thompson R, Rampertaap S, Stoddard J, Ware J, Fay MP, Holland-Thomas N, Nutman TB, Klion AD. Clin Infect Dis. 2021 Oct 5;73(7):e1624-e1631. doi: 10.1093/cid/ciaa1365. PMID: 32910141

Infection-associated Immune Perturbations Resolve 1 Year Following Treatment for Loa loa. Herrick JA, Makiya MA, Holland-Thomas N, Klion AD, Nutman TB. Clin Infect Dis. 2021 Mar 1;72(5):789-796. doi: 10.1093/cid/ciaa137. PMID: 32055862

Single-Organ and Multisystem Hypereosinophilic Syndrome Patients with Gastrointestinal Manifestations Share Common Characteristics. Kuang FL, Curtin BF, Alao H, Piligian B, Berry A, Holland-Thomas N, Powers A, Quezado M, Lumbard K, Fay MP, Klion AD, Kumar S, Khoury P.J Allergy Clin Immunol Pract. 2020 Sep;8(8):2718-2726.e2. doi: 10.1016/j.jaip.2020.04.025. Epub 2020 Apr 25.PMID: 32344186 
 
Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome. Kuang FL, Legrand F, Makiya M, Ware J, Wetzler L, Brown T, Magee T, Piligian B, Yoon P, Ellis JH, Sun X, Panch SR, Powers A, Alao H, Kumar S, Quezado M, Yan L, Lee N, Kolbeck R, Newbold P, Goldman M, Fay MP, Khoury P, Maric I, Klion AD.N Engl J Med. 2019 Apr 4;380(14):1336-1346. doi: 10.1056/NEJMoa1812185.PMID: 30943337 Free PMC article. Clinical Trial.

Research Group

Clinicians





A headshot of Thomas Nutman in a white shirt.

Thomas Nutman, MD
Senior Investigator





A headshot of Amy Klion in a green shirt.

Amy Klion, MD
Senior Investigator





A headshot of Paneez Khoury in a lab coat.

Paneez Khoury, MD
Associate Research Physician





A headshot of Elise O'Connell in a lab coat.

Elise O'Connell, MD
Associate Research Physician





A headshot of Gregory Constantine in a blue shirt.

Gregory Constantine, MD
Assistant Research Physician





A headshot of Adrienne Showler with a blue background.

Adrienne Showler, MD
Attending Physician

William Sears, MD
Clinical Infectious Diseases Fellow





A headshot of Janitzio Guzman in a suit and a tie.

Janitzio Guzman, MD
Clinical Infectious Diseases Fellow





A headshot of JeanAnne Ware with a tan background.

JeanAnne Ware, CRNP
Nurse Practitioner





A headshot of Lauren Weltzer in a lab coat.

Lauren Wetzler, MHS, PA-C
Physician Assistant

Celeste Nelson, CRNP
Nurse Practitioner

Study Coordinators

Nicole Holland, MSN, RN
Nurse Research Specialist





A headshot of Thomas Brown in a gray shirt.

Thomas Brown, RN
Nurse Specialist, CCRP

Lauren Thumm, MSN, RN
Protocol Nurse Coordinator II

Perla Adames Castillo, RN 
Nurse Research Specialist

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