Major Areas of Research
- Clinical definition and pathogenesis underlying parasitic diseases
- New methods of diagnosis of parasitic infections
- Therapeutic interventions in parasitic infections
- Hypereosinophilic syndromes (HES): from pathogenesis to novel therapeutic interventions
The Clinical Parasitology Section is an interdisciplinary group of clinically trained LPD staff members who oversee the clinical research portfolio and provide clinical care, consultations, and training in tropical medicine and parasitology. The overriding goals of this program are
- To gain insight into the clinical syndromes associated with parasitic infections
- To understand and help define the pathogenesis underlying clinical disease
- To identify better ways of treating individual infections and to prevent secondary consequences of treatment
- To develop better diagnostic tools for the species-specific diagnosis of active parasitic infection
Although the Clinical Parasitology Section has protocols to see patients with any parasitic infection, the overwhelming majority of patients have neurocysticercosis, filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis), strongyloidiasis, hookworm infections, ascaraisis, giardiasis, echinococcosis, and leishmaniasis. We occasionally see patients with gnathostomiasis, African trypanosomiasis, Chagas disease, and malaria, among others.
Bisoffi Z, Buonfrate D, Sequi M, Mejia R, Cimino RO, Krolewiecki AJ, Albonico M, Gobbo M, Bonafini S, Angheben A, Requena-Mendez A, Muñoz J, Nutman TB. Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection. PLoS Negl Trop Dis. 2014 Jan 9;8(1):e2640.
Khoury P, Herold J, Alpaugh A, Dinerman E, Holland-Thomas N, Stoddard J, Gurprasad S, Maric I, Simakova O, Schwartz LB, Fong J, Lee CC, Xi L, Wang Z, Raffeld M, Klion AD. Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder. Haematologica. 2015 Mar;100(3):300-7.
Mahanty S, Orrego MA, Mayta H, Marzal M, Cangalaya C, Paredes A, Gonzales-Gustavson E, Arroyo G, Gonzalez AE, Guerra-Giraldez C, García HH, Nash TE; Cysticercosis Working Group in Peru. Post-treatment vascular leakage and inflammatory responses around brain cysts in porcine neurocysticercosis. PLoS Negl Trop Dis. 2015 Mar 16;9(3):e0003577.
Nash TE, Mahanty S, Loeb JA, Theodore WH, Friedman A, Sander JW, Singh G, Cavalheiro E, Del Brutto OH, Takayanagui OM, Fleury A, Verastegui M, Preux PM, Montano S, Pretell EJ, White AC Jr, Gonzales AE, Gilman RH, Garcia HH. Neurocysticercosis: A natural human model of epileptogenesis. Epilepsia. 2015 Feb;56(2):177-83.
O'Connell EM, Nutman TB. Eosinophilia in infectious diseases. Immunol Allergy Clin North Am. 2015 Aug;35(3):493-522.
Domestic (NIH Clinical Center, Bethesda, Maryland)
A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Single-Dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection, NCT01111305
A double-blinded, randomized, placebo-controlled dose escalation study to examine the microfilaricidal kinetics and safety of imatinib for the treatment of Loa loa
Effect of concomitant Mansonella perstans microfilaremia on immune responses following single dose praziquantel in subjects with schistosomiasis: a pilot study