Major Areas of Research
- Characterization and treatment of eosinophilic disorders
- Eosinophil responses to glucocorticoids
- Clinical trials in rare eosinophilic disorders
- Patient- and clinician-reported outcome measures in eosinophilic disorders
In the Human Eosinophil Section, Dr. Khoury is an investigator on protocols focused on eosinophilic disorders including hypereosinophilic syndromes (HES), overlap HES disorders such as eosinophilic granulomatosis with polyangiitis (EGPA), eosinophilic gastrointestinal disorders (EGID), episodic angioedema with eosinophilia (EAE; Gleich’s syndrome), and eosinophilic fasciitis. Many of the protocols investigate novel therapeutic approaches including targeting eosinophils and/or mast cells, as well as translational approaches to understanding the pathogenesis of these rare diseases. She has a particular interest in treatment-refractory and difficult-to-treat HES and EGID.
Paneez Khoury, M.D. is an associate research physician at NIAID. She has been involved in translational research in eosinophilic disorders since joining the Human Eosinophil Section in 2012.
She received her M.D. from University of Illinois College of Medicine in Chicago. She completed an internal medicine residency at the Ohio State University followed by a fellowship in allergy and clinical immunology at NIH. She also holds a master’s of health sciences from Duke University. She is board certified in internal medicine and allergy/immunology and is a fellow of the American Academy of Allergy, Asthma and Immunology (AAAAI).
At NIH, she serves as the chair of the Scientific Review Committee of the Laboratory of Parasitic Diseases and serves on the NIH and NIAID investigational review board. Her external committee activities include involvement in the food allergy and eosinophilic disorders committee of AAAAI and participating in the AAAAI Leadership Institute. She serves on the board of the International Eosinophil Society (IES) and is the social media editor for the society. She is a member of the American College of Physicians and the American Medical Association. She is a site investigator for the Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR) through the NCATS Rare Diseases Clinical Research Network.
Kuang FL, Legrand F, Makiya M, Ware J, Wetzler L, Brown T, Magee T, Piligian B, Yoon P, Ellis JH, Sun X, Panch SR, Powers A, Alao H, Kumar S, Quezado M, Yan L, Lee N, Kolbeck R, Newbold P, Goldman M, Fay MP, Khoury P, Maric I, Klion AD. Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome. N Engl J Med. 2019 Apr 4;380(14):1336-1346.
Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). J Leukoc Biol. 2018 Jul;104(1):69-83.
Khoury P, Abiodun AO, Holland-Thomas N, Fay MP, Klion AD. Hypereosinophilic Syndrome Subtype Predicts Responsiveness to Glucocorticoids. J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):190-195.
Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ; EGPA Mepolizumab Study Team. Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. N Engl J Med. 2017 May 18;376(20):1921-1932.
Khoury P, Herold J, Alpaugh A, Dinerman E, Holland-Thomas N, Stoddard J, Gurprasad S, Maric I, Simakova O, Schwartz LB, Fong J, Lee CC, Xi L, Wang Z, Raffeld M, Klion AD. Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder. Haematologica. 2015 Mar;100(3):300-7.
Khoury P, Grayson PC, Klion AD. Eosinophils in vasculitis: characteristics and roles in pathogenesis. Nat Rev Rheumatol. 2014 Aug;10(8):474-83.
Steroid Treatment for Hypereosinophilic Syndrome, NCT01524536