Elodie Ghedin, Ph.D.

Elodie Ghedin, Ph.D.

Credit: NIAID
Chief, Systems Genomics Section
  • Respiratory virus transmission and evolution
  • Microbial interactions in respiratory infections (influenza, COVID-19, tuberculosis)
  • Host-parasite interactions in filarial worm infections

Biography

Dr. Elodie Ghedin obtained her Ph.D. from McGill University’s Institute of Parasitology in Montreal, Canada. Following a postdoctoral fellowship at NIAID on the cell biology of Leishmania donovani, in 2000 she joined The Institute for Genomic Research (TIGR; now the J. Craig Venter Institute) where she worked on the annotation of trypanosomatid genomes. There she led her own group on the Brugia malayi and Influenza Virus genome projects. In 2006 she joined the University of Pittsburgh School of Medicine where she was part of the Department of Computational and Systems Biology and the Center for Vaccine Research. In 2014 she moved to New York University where she was a professor of biology in the College of Arts and Sciences, and a professor of epidemiology in the School of Global Public Health. From 2017 to 2019, she served as director of NYU’s Center for Genomics and Systems Biology. In May 2020, Dr. Ghedin joined NIAID’s Laboratory of Parasitic Diseases as a senior investigator. She also holds an affiliated position with New York University. Dr. Ghedin is a MacArthur Foundation Fellow (2011), a Kavli Frontier of Science Fellow (2012), and an American Academy of Microbiology Fellow (2017).

Program Description

Our systems biology research program meets at the interface of microbiology, molecular virology, systems biology, and genomics and focuses on the molecular basis of microparasite (virus and bacteria) diversity and interaction in transmission and virulence and macroparasite (nematodes) adaptation to niches in their human hosts. The overarching question is, How do pathogens adapt to their hosts, and what is the evolutionary basis of this adaptation?

Predictive modeling of clinical outcomes in respiratory infections

We develop and use new analytical tools to define genetic structure and mechanisms of evolutionary change in respiratory viruses sampled within individual hosts over the course of an infection and across chains of transmission. We have observed that the dynamics of evolution of respiratory viruses like influenza are different in pre-immune versus naïve hosts and in high-risk populations, such as immunocompromised and obese individuals. In light of the COVID-19 pandemic, we have expanded our research program to include SARS-CoV-2 to pursue questions on transmission, factors associated with disease severity, and host selection pressure on the evolution of the virus. Our goal is to integrate systems-wide data and map molecular interaction networks to build predictive models of COVID-19 severity. (Collaborations with Dr. Lara Mahal, University of Alberta; Dr. Stacey Schultz-Cherry, St. Jude Children’s Research Hospital; Dr. David Gresham, Center for Genomics and Systems Biology, New York University; Dr. Ted Ross, University of Georgia; Dr. Mirella Salvatore, Weil Cornell Medicine)

Related Projects

  • Determining intra-host diversity and phylogeny of SARS-CoV-2 (collaborations with Dr. Mark Mulligan, New York University Grossman School of Medicine; Dr. Sanchita Das, NIH Clinical Center; Dr. Marta Luksza, Icahn School of Medicine at Mt. Sinai; Dr. Michael Lassig, University of Cologne; Dr. Robert Paulino Ramirez, Universidad Iberoamericana, Dominican Republic; Dr. Jacques Boncy, Ministry of Health, Haiti)
  • Profiling the respiratory microbiome and antibiotic resistance (collaborations with Dr. Leopold Segal, New York University Langone; Dr. Richard Bonneau, New York University and the Flatiron Institute; Dr. Aubree Gordon, University of Michigan; Dr. Anna Roca, LSHTM/MRC, The Gambia)
  • Functional analyses of the respiratory microbiome in tuberculosis (collaboration with Dr. Philana Lin and Dr. JoAnne Flynn, University of Pittsburgh School of Medicine)

Filarial nematodes infect millions of individuals and represent the leading cause of morbidity in the developing world. Current medications are inadequate for control and elimination, necessitating a better understanding of the basic biology of these worms. Most filarial nematodes, including Brugia malayi and Onchocerca volvulus (causative agents of lymphatic filariasis and river blindness, respectively) have an essential intracellular bacterial endosymbiont, Wolbachia. Our studies address key questions on the reciprocal cues required in the co-dependency between the worm and the bacteria.

Related Projects

  • Modeling the interplay between filarial worms and their endosymbiont (collaborations with Dr. Stefania Giacomello, ScieLifeLab, Sweden; Dr. John Parkinson, University of Toronto; Dr. Sara Lustigman, New York Blood Center)
  • Identifying promoter motifs involved in nematode development (collaborations with Dr. Lonnie Welch, Ohio University; Dr. Thomas Unnasch, University of South Florida)
  • Discovering new metabolites and immunomodulators (collaborations with Dr. Drew Jones, New York University Grossman School of Medicine; Dr. Dirk Trauner, New York University)

Research Group

Denis Voronin, Ph.D.
Staff Scientist
M.S., Biology, Novosibirsk State University, Russia
PhD, Institute of Cytology and Genetics, Novosibirsk, Russia

Denis trained as a postdoctorate fellow at Université Claude Bernard Lyon 1 and at the Liverpool School of Tropical Medicine before joining the New York Blood Center where he became Assistant Member of the Cellular Microbiology Research Program. Denis is focused on delineating the essential cellular processes that define symbiotic Wolbachia-host interactions in filarial nematodes. Elimination of the symbiont leads to death of the adult worm, rendering Wolbachia an attractive target for interventional tools to combat filariasis.

Martha Nelson, Ph.D.
Visiting Staff Scientist
B.A. Biology, Amherst College, MA
Ph.D. Biology, The Pennsylvania State University, PA

Martha was a Research Fellow and Staff Scientist at the Division of International Epidemiology and Populations Studies (DIEPS) of the Fogarty International Center. She is currently a visiting fellow in SGS to pursue her work in influenza and SARS-CoV-2 genomic epidemiology.

Yin-Ting (Tim) Yeh, Ph.D.
Visiting Scientist (Research Assistant Prof, PSU)
B.S., Engineering and System Science, and Material Science Engineering, National Tsing-Hua University, Taiwan
M.S., Chemical and Biochemical Engineering, University of Notre-Dame, IN
Ph.D., Biomedical Engineering, The Pennsylvania State University, PA

Tim is a visiting scientist in SGS. His research focuses on a combination of enhanced Raman spectroscopy, the development and application of a virus enrichment microfluidic device, and suitable deep learning algorithms to rapidly detect viruses, their antigenic variants and track genetic and antigenic evolution in real-time. This work is part of collaborations with Dr. Mauricio Terrones at PSU, and Dr. Steve Jacobson at NINDS/NIH.

Allison Roder, Ph.D.
Computational Biologist
B.S., Biotechnology and Molecular Bioscience, and Computer Science, Rochester Institute of Technology
PhD, Molecular Genetics and Microbiology, Duke University

Allison is studying the evolution of SARS-CoV-2 in populations at risk, and the host response to Influenza A and B viruses.

Matthew Chung, Ph.D.
Computational Biologist
B.S., Microbiology, G. H. Cook Scholar, Rutgers University, NJ
PhD, Molecular Microbiology and Immunology, Institute for Genome Sciences, University of Maryland Baltimore

Matt specializes in the computational analysis of genomics, metagenomics, and transcriptomics data sets in the analysis of the respiratory microbiome in COVID19 and COPD patients.

Stephanie Banakis, M.S.
Lab Manager and Biologist
B.S., Bioengineering, University of Illinois at Chicago
M.S., Biology, New York University

Stephanie studies the evolution of the Influenza virus and of SARS-CoV-2 in populations at risk.

Wei Wang, M.S.
Biologist
Bachelor of Medicine, Tongji Medical University, Wuhan, China
M.S., Microbiology, North Dakota State University, ND

Wei has over 20 years of experience in cell culture with expertise in molecular virology and vaccine research.

Joseph Koussa, Ph.D.
Post-doctoral IRTA
B.Sc., Biology, University of Ottawa, Canada
M.S., Molecular Biology, Lebanese American University, Lebanon

Joe held a faculty position at New York University Abu Dhabi where he served as an Instructor in the Division of Natural Sciences for four years.

Joe’s project revolves around host-parasite interactions in lymphatic filariasis with an emphasis on sex-dependent interactions between adult male and female parasitic worms and the host’s lymphatic endothelial cells. He has a keen interest in glycobiology of host-parasite interactions and adopts a glycocentric approach to the identification of biologically active effector parasite molecules.

Alexandra Mushegian, Ph.D.
Post-doctoral IRTA
A.B., Organismic and Evolutionary Biology, Harvard University
Ph.D., Universitat Basel, Zoology

Sasha is broadly interested in the ecology and evolution of pathogens, parasites and vectors. In the SGS lab, she is working on SARS-CoV-2. One set of questions revolves around within-host viral diversity of clinical samples and whether it can help us inform epidemiological surveillance or clinical practice. A second project is on characterizing the genomic epidemiology of SARS-CoV-2 in the Caribbean.

Abdoulie Bojang, Ph.D.
Post-doctoral Visiting IRTA (APTI)
B.Sc., Bioscience and Health, Leeds Metropolitan University, UK
M.Sc., Biomedical science, University of Hull, UK
Ph.D., Open University, UK
Higher scientific officer, Medical Research Council unit, The Gambia
Postdoctoral researcher, Medical Research Council unit, The Gambia

Abdoulie joined SGS in August 2021. His project in the SGS is to assess by metagenomics the impact of intrapartum oral azithromycin on the nasopharyngeal microbiome of Gambian infants.  Oral azithromycin given during labor appears to be a promising intervention to ultimately decrease neonatal mortality and to reduce incidence of clinical infection among mother (mastitis, fever) and their babies (skin infection).  However, the impact of the intervention on the nasopharyngeal microbiome of infants is not yet known.  

Michael Frimpong, Ph.D.
Post-doctoral Visiting IRTA (APTI)
B.Sc., Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Ph.D., Immunity and Infectious Diseases, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Michael joined SGS in August 2021. His research is focused on using metagenomics to understand the pathogenesis of skin neglected tropical diseases, particularly Buruli ulcer and how that information can be used to improve treatment outcomes.

Brent Edwards, B.A.
Post-bac IRTA
B.A., Biology, Middlebury College, VT

Brent is mentored by Dr. Denis Voronin and his project is focused on the intracellular bacteria Wolbachia and the mechanisms by which the bacteria interacts with its mosquito and filarial nematode hosts. Specifically, he is studying the effects of Wolbachia in mosquito cells infected with Zika virus and the molecular basis for why Wolbachia presence is associated with Zika virus suppression. A second project investigates the endosymbiotic relationship between Wolbachia and filarial nematodes to identify potential drug targets for the treatment and prevention of lymphatic filariasis.

Anil Chakravorty, B.S.
Post-bac IRTA
B.S., Integrative Biology Honors program, minor in Chemistry, University of Illinois at Urbana-Champaign, IL

Anil works with Dr. Allison Roder and investigates the gene expression profiles of host cells in response to infection with Influenza A and B. Currently, most transcriptomic analyses focus on influenza A infection, in part due to its pandemic potential; there is a paucity of information regarding host response to influenza B infection.

Christopher Mederos, B.S.
Post-bac IRTA
B.S., Biochemistry, Florida International University in Miami, FL.

Chris is working on two projects. The first, under the mentorship of Dr. Allison Roder, is to investigate the evolutionary transmission dynamics of SARS-CoV-2 and intra-host single nucleotide variants (iSNVs). The second project, under the mentorship of Dr. Joe Koussa, investigates the role of secreted lipid-binding proteins in the infection of Brugia malayi in humans.

Daniela Chow, B.S.
Post-bac IRTA (INRO)
B.S., Biological Sciences, The University of Texas at El Paso, TX

Daniela, under the mentorship of Dr. Joe Koussa, is studying the interplay of Brugia malayi with human lymphatic endothelial cells and its contribution in pathogenesis. She is also determining the role of Brugia malayi Galectin-2 (lec-2) in host-parasite interactions.

Allie Kreitman, B.A.
Post-bac IRTA (INRO)
B.A., Molecular Biology, minor in Math, Colorado College, CO

Allie’s project, under the mentorship of Dr. Sasha Mushegian, is to characterize the genomic epidemiology of SARS-CoV-2 in the Dominican Republic and Haiti. She is also comparing samples collected from symptomatic and asymptomatic individuals infected with SARS-CoV-2.

RyeAnne Ricker, B.S.
Ph.D. candidate, Biomedical Engineering, George Washington University
B.S., Biological Engineering, Montana State University, MT
B.S., Microbiology – Medical Laboratory Science, Montana State University, MT

RyeAnne worked as a microbiologist for 2 years at the Public health Labs for the State of Washington, Division of Disease Control & Health Statistics, before starting her graduate program at GWU. In her graduate research in SGS, she uses Machine Learning techniques to characterize viruses by their Raman spectrum. The aim of this work is to generate rapid methods for detection and identification of viruses as well as to better understand how a Raman fingerprint can be used to infer relationships between viruses.

RyeAnne is a National Science Foundation Fellow (2021-2024), and she has received the 2021 Terry Collins Distinguished Doctoral Award.

Selected Publications

Visit PubMed for a complete publication list.

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