Human Eosinophil Section
Gregory M. Constantine, M.D. (He/Him/His)
Assistant Research Physician, Human Eosinophil Section (HES), Laboratory of Parasitic Diseases (LPD)
Contact: For contact information, search the NIH Enterprise Directory.
Specialty(s): Allergy and Immunology, Internal Medicine Provides direct clinical care to patients at NIH Clinical Center
- Characterization and treatment of eosinophilic disorders, including eosinophilic esophagitis (EoE) and other eosinophilic gastrointestinal disorders (EGID), and hypereosinophilic syndromes (HES).
- Sensory mechanisms of EGID-related symptoms
- Role of environment and immigration on eosinophilic disorders
- Eosinophil biology and maturation
Program Description
In the Human Eosinophil Section, Dr. Constantine is an investigator on multiple protocols addressing eosinophilic disorders including eosinophilic esophagitis and other EGIDs and serves as a site-investigator for the Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR) through NIH/NCATS/RDCRN.
Dr. Constantine’s research is focused on understanding tissue remodeling and neuroimmune mechanisms that may underpin ongoing symptoms in patients with eosinophilic gastrointestinal diseases. Additionally, we are interested in the influence of immigration and other environmental factors associated with EGID-risk. Our clinical studies hope to improve EGID diagnosis among historically underrepresented ethnic and racial minority patient populations and those with limited access to specialty care through implementation of minimally invasive diagnostic tools.
Biography
Education
M.D., University of Texas Long School of Medicine, San Antonio, TX
Residency, Internal Medicine, Baylor College of Medicine, Houston, TX
Chief Residency, Internal Medicine, Baylor College of Medicine, Houston, TX
Fellowship, Allergy and Immunology, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD
Gregory Constantine, M.D. is an Assistant Research Physician Clinician in NIAID. He has been involved in translational research in eosinophilic disorders since joining the Human Eosinophil Section in 2020.
He received his M.D. from University of Texas Long School of Medicine, followed by Internal Medicine residency at Baylor College of Medicine (BCM). He was then selected and served as Chief Resident and Clinical Instructor at BCM before completing subspecialty training in Allergy and Immunology at NIH.
At NIH, he serves on the FDA-NIH Immunology Interest Group Committee and as a core faculty member for Allergy/Immunology fellowship training program. His external committee activities include involvement in the Eosinophilic Gastrointestinal Disorders and Cells and Mediators of Allergic Inflammation Committees through the American Academy of Allergy, Asthma & Immunology.
Clinical Studies
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia, NCT00001406, Associate Investigator
Zemaira Eosinophilic Esophagitis Pilot Study (ZEEPS), NCT05485155, Principal Investigator
Selected Publications
Constantine GM, Klion AD. Recent advances in understanding the role of eosinophils. Fac Rev. 2022;11:26.
Constantine GM, Ware J, Brown T, Thumm L, Kamal N, Kumar S, Kleiner D, Maric I, Klion AD. Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease. J Allergy Clin Immunol Pract. 2020;8(6):2089-91.
Constantine G, Seth N, Chokshi N, Minard CG, Guffey D, Olive AP, Davis CM. Combination Steroid and Test-based Food Elimination for Eosinophilic Esophagitis: A Retrospective Analysis. J Pediatr Gastroenterol Nutr. 2017;64(6):933-8.
Hiremath G, Byramji D, Pacheco A, Constantine G, Davis C, Shulman R, Olive A. Eosinophilic Esophagitis in Children and Its Relationship with Parental Allergies: Texas Children’s Hospital Experience. Dig Dis Sci. 2016;61(2):501-506. doi:10.1007/s10620-015-3903-6
Research Network
Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR)