Our research program is focused on the design, implementation, and interpretation of screening efforts to identify and determine the interactions among the components in both TLR and inflammasome signaling networks. We use high-throughput genetic screening to identify key pathway regulators, and a combination of cell biology, biochemistry, and molecular biology to characterize their function. Our goal is to obtain a better understanding of how innate immune signaling pathways control the macrophage inflammatory state, and ultimately to develop strategies to regulate these responses in human inflammatory diseases. Specific projects of our research group members in this context are described in their Bio sections below.
Iain Fraser, Ph.D.
Chief, Signaling Systems Section
Specialty(s): Allergy and Immunology, Infectious Disease
Ph.D., Imperial College, University of London
Rahul Basu, Ph.D.
Ph.D., Indian Institute of Science Education and Research (IISER), Kolkata, India
Clinton Bradfield, Ph.D.
Ph.D., microbial pathogenesis, Yale University
M.S., microbial pathogenesis, Yale University
B.A., Biochemistry, Simpson College
University of California Berkeley
Brown University, Providence, RI
Sinu P. John, Ph.D. (He/Him/His)
Ph.D., 2006, University of Alabama, Birmingham, AL, USA
M.Sc., 1999, University of Hyderabad, India
Languages Spoken: Malayalam
Sam Katz, Ph.D.
Ph.D., 2020, University of Cambridge
Camille Lake, Ph.D.
Rotating Fellow, NIAID’s Emerging Leaders in Data Science Fellowship Program
Ph.D., Infectious Diseases and Immunology, Uniformed Services University of the Health Sciences
Yale University, New Haven, CT
Master’s Degree, University of Cambridge
Makheni Jean Pierre, B.S.
B.S., Stony Brook University
Jing Sun, Ph.D., M.D
Ph.D., Peking University, China
M.D., Peking University, China