Fraser Research Group

Our research program is focused on the design, implementation, and interpretation of screening efforts to identify and determine the interactions among the components in both TLR and inflammasome signaling networks. We use high-throughput genetic screening to identify key pathway regulators, and a combination of cell biology, biochemistry, and molecular biology to characterize their function. Our goal is to obtain a better understanding of how innate immune signaling pathways control the macrophage inflammatory state, and ultimately to develop strategies to regulate these responses in human inflammatory diseases. Specific projects of our research group members in this context are described in their Bio sections below.

Iain Fraser, Ph.D.

Chief, Signaling Systems Section

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Specialty(s): Allergy and Immunology, Infectious Disease

Education:

Ph.D., Imperial College, University of London

Iain Fraser, Ph.D., is the Chief of the Signaling Systems Section. Our research program is focused on the design, implementation, and interpretation of screening efforts to identify and determine the interactions among the components in PRR signaling networks. Our goal is to obtain a better understanding of how PRR signaling pathways control the macrophage inflammatory state, and ultimately to develop strategies to regulate these responses in human inflammatory diseases.

Iain Fraser, Ph.D.

Rahul Basu, Ph.D.

Postdoctoral Fellow

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Education:

Ph.D., Indian Institute of Science Education and Research (IISER), Kolkata, India

Rahul Basu is a postdoctoral fellow under the Rocky Mountain Lab (RML)-Bethesda (Rocky-Beth) collaborative program. He received his Ph.D. from the Indian Institute of Science Education and Research (IISER) Kolkata, India where his project was directed to understand the changes in neuroglial interaction in a murine coronavirus infection model. In 2017, he joined Dr. Karin Peterson’s Neuroimmunology
Rahul Basu headshot

Clinton Bradfield, Ph.D.

Research Fellow

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Education:

Ph.D., microbial pathogenesis, Yale University
M.S., microbial pathogenesis, Yale University
B.A., Biochemistry, Simpson College

Clinton Bradfield is a Research Fellow in the Signaling Systems Section. Originally from Essex, Iowa, he received his BA in Biochemistry from Simpson College where he discovered his interest in molecular biology, organic chemistry, and microbial pathogenesis. Following early exposure to transcriptional analyses (P. Singer), chemical synthesis (T. Nguyen), and viral replication (R. Roller, M. Robek
Clinton Bradfield headshot

Asmaysinh Gharia

Graduate Student

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Education:

NIH Oxford-Cambridge
University of California Berkeley

Asmaysinh Gharia is a graduate student in the NIH Oxford-Cambridge Scholars program.

Asmaysinh Gharia headshot

Julia Gross

Graduate Student

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Education:

Brown University, Providence, RI

Julia Gross is a graduate student in the NIH GPP/Emory IMP program. She hails from San Francisco, CA, where she studied as an undergrad at Brown University in Providence, RI, and currently lives in Washington D.C. while working on her thesis at NIAID. Her project is centered on understanding how different types of antibiotic treatments impact patients’ immune responses to bacterial infections
Julia Gross headshot

Sinu John, Ph.D.

Staff Scientist

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Education:

Ph.D., University of Alabama at Birmingham
Post-doctoral work, Harvard Medical School and the Ragon Institute of MGH, Harvard and MIT

Sinu P. John is a Staff Scientist in the Signaling Systems Section. He received his Ph.D. from the University of Alabama at Birmingham and did his post-doctoral work at Harvard Medical School and the Ragon Institute of MGH, Harvard and MIT. His research currently focuses on identifying and understanding the mechanism of genetic and small molecule modulators of macrophage function. Dr. John uses
Sinu John

Sam Katz, Ph.D.

Postdoctoral Fellow

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Education:

Ph.D., 2020, University of Cambridge

Sam Katz joined the Signaling Systems Section as a graduate student in the NIH-OxCam program in 2016.

Sam Katz headshot

Camille Lake, Ph.D.

Rotating Fellow, NIAID’s Emerging Leaders in Data Science Fellowship Program

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Education:

Ph.D., Infectious Diseases and Immunology, Uniformed Services University of the Health Sciences

Camille Lake is a rotating fellow in NIAID’s Emerging Leaders in Data Science Fellowship program. She spent her upbringing in the hills of Northern California, and eventually moved to Santa Barbara where she got her college degree and discovered her love of molecular biology.

Camille Lake headshot

Jonathan Liang

M.D./Ph.D. Student

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Education:

Yale University, New Haven, CT
Master’s Degree, University of Cambridge

Jonathan Liang is an M.D./Ph.D. student who has recently completed his graduate work through the NIH-OxCam Scholars Program.

Jonathan Liang headshot

Makheni Jean Pierre, B.S.

Postbaccalaureate Fellow

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Education:

B.S., Stony Brook University

Makheni Jean Pierre is a postbaccalaureate fellow who joined the Signaling Systems Section in 2020 through the Undergraduate Scholarship Program (UGSP). He obtained his associate degree in science from Queensborough Community College (QCC New York) then transferred to Stony Brook University to complete his bachelor’s in biology. His interest lies in the intracellular signaling processes in
Makheni Jean Pierre headshot

Jing Sun, Ph.D., M.D

Biologist

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Education:

Ph.D., Peking University, China
M.D., Peking University, China

Jing Sun is the Ph.D. level Biologist in the Signaling Systems Section. She received her Ph.D./M.D. from Peking University, China, and was trained at Harvard Medical school and NIH before promotion to the Biologist position in 2014. Jing is currently leading multiple projects investigating mechanistic aspects of TLR signaling, with a particular focus on IRAK function and the role of Ubiquitin
Jing Sun headshot
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