Our research program is focused on the design, implementation, and interpretation of screening efforts to identify and determine the interactions among the components in both TLR and inflammasome signaling networks. We use high-throughput genetic screening to identify key pathway regulators, and a combination of cell biology, biochemistry, and molecular biology to characterize their function. Our goal is to obtain a better understanding of how innate immune signaling pathways control the macrophage inflammatory state, and ultimately to develop strategies to regulate these responses in human inflammatory diseases. Specific projects of our research group members in this context are described in their Bio sections below.
Signaling Systems Section, 2022. Front Row (left to right): Sam Katz, Postdoctoral Fellow, Jing Sun, Research Biologist, Clinton Bradfield, Research Fellow. Back Row (left to right): Sinu John, Staff Scientist, Camile Lake, NIAID Data Science Fellow, Yamini Nallana, Georgetown Masters Student, Iain Fraser, Senior Investigator, Makheni Jean-Pierre, Postbaccalaureate Fellow, Julia Gross, Graduate Student, Rahul Basu, Postdoctoral Fellow.
Iain Fraser, Ph.D.
Chief, Signaling Systems Section
Specialty(s): Allergy and Immunology, Infectious Disease
Education:
Ph.D., Imperial College, University of London
Rahul Basu, Ph.D.
Postdoctoral Fellow
Education:
Ph.D., Indian Institute of Science Education and Research (IISER), Kolkata, India
Clinton Bradfield, Ph.D.
Research Fellow
Education:
Ph.D., microbial pathogenesis, Yale University
M.S., microbial pathogenesis, Yale University
B.A., Biochemistry, Simpson College
Asmaysinh Gharia
Graduate Student
Education:
NIH Oxford-Cambridge
University of California Berkeley
Julia Gross
Graduate Student
Education:
Brown University, Providence, RI
Sinu P. John, Ph.D. (He/Him/His)
Staff Scientist
Education:
Ph.D., 2006, University of Alabama, Birmingham, AL, USA
M.Sc., 1999, University of Hyderabad, India
Languages Spoken: Malayalam
Sam Katz, Ph.D.
Postdoctoral Fellow
Education:
Ph.D., 2020, University of Cambridge
Camille Lake, Ph.D.
Rotating Fellow, NIAID’s Emerging Leaders in Data Science Fellowship Program
Education:
Ph.D., Infectious Diseases and Immunology, Uniformed Services University of the Health Sciences
Jonathan Liang
M.D./Ph.D. Student
Education:
Yale University, New Haven, CT
Master’s Degree, University of Cambridge
Makheni Jean Pierre, B.S.
Postbaccalaureate Fellow
Education:
B.S., Stony Brook University
Jing Sun, Ph.D., M.D
Biologist
Education:
Ph.D., Peking University, China
M.D., Peking University, China
