Molecular Defenses Section
Howard E. Boudreau, Ph.D.
Staff Scientist
Provides direct clinical care to patients at NIH Clinical Center
Major Areas of Research
- NADPH oxidase (NOX) enzyme function
- Inflammation
- Wound healing
- Cancer metastasis
Program Description
We are currently investigating the role of mutant p53-induced NOX4 on the cancer cell secretome, and the effects NOX4-derived reactive oxygen species have on the inflammatory tumor microenvironment.
Biography
Education
Ph.D., 2006, Georgetown University
Howard Boudreau obtained his Ph.D. in Biochemistry and Molecular & Cellular Biology from Georgetown University in 2006. His graduate work focused on identifying and characterizing novel effector targets of the Raf-1/ERK signaling pathway in metastatic breast cancer. As a post-doctoral fellow at NIH/NIAID, he focused on roles of NADPH oxidase (NOX) enzymes in TGF-beta-mediated inflammation and wound healing. In 2014, he joined the Molecular Defenses Section (MDS) as a Staff Scientist in the Laboratory of Clinical Immunology and Microbiology (LCIM) and studies how tumor-associated mutant p53 proteins and NOX4 contribute to cancer cell migration and inflammation.
Selected Publications
Ma WF, Boudreau HE, Leto TL. Pan-Cancer Analysis Shows TP53 Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome. Antioxidants (Basel). 2021 Feb 4;10(2):235.
Boudreau HE, Leto TL. Model Systems to Investigate NOX-Dependent Cell Migration and Invasiveness. Methods Mol Biol. 2019;1982:473-485.
Sugamata R, Donko A, Murakami Y, Boudreau HE, Qi CF, Kwon J, Leto TL. Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide. J Immunol. 2019 Jan 15;202(2):428-440.
Boudreau HE, Ma WF, Korzeniowska A, Park JJ, Bhagwat MA, Leto TL. Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53. Oncotarget. 2017 Jul 4;8(27):44379-44397.
Boudreau HE, Casterline BW, Burke DJ, Leto TL. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82.