Mathematical Biologist, Biostatistics Research Branch
Single Photon Emission Computed Tomography (SPECT\CT) and Positron Emission Tomography(PET\CT) In Vivo Imaging of Nonhuman Primates in the setting of Simian-Acquired-Immunodeficiency-Syndrome.
Laboratory scientific and budgetary oversight for the development and experimental testing In Vitro and In Vivo of novel radiolabeled-probes at the National Institute of Health Animal Center (AIDS Imaging Research Section AIRS Laboratory)\Poolesville, MD) in the following areas of application: Whole body CD4- pool and Immune activation, Antiviral drug-delivery strategies (Lipid-based nanoparticles) and whole-body pharmacokinetics, Viral replication in anatomic compartments, Neuroinflammation.
Mathematical modeling of viral dynamics, lymphocyte turnover and immune activation in HIV infected patients and related model systems; Mathematical modeling of Nuclear Medicine In-Vivo Imaging and In-Vitro data produced at the AIRS laboratory in Poolesville.
Evaluation of an antibody to Alpha4Beta7 in the control of SIV infection. Di Mascio M., Lifson J.J., Srinivasula S., DeGrange P., Keele B., Proschan M., Lane H.C., Fauci A.S. (Science, 2019 Sep 6; 354(6457):1025-1029).
Microglial activation is inversely correlated to CSF viral load in the setting of severe SIV encephalitis. Hammoud D.A, Sinharay S., Shah S., Schreiber-Stainthorp W., Maric D., Muthusamy S., Lee D.E., Lee C., Bhattacharyya F., Reid W. C., Wakim P., Matsuda K., Hirsch V., Nath A., Di Mascio M. (mBio, 2019 May 28;10(3)).
Total body CD4+ T cell dynamics in treated and untreated SIV infection revealed by in vivo imaging. Di Mascio M, Srinivasula S, Kim I, Duralde G, St Claire A, DeGrange P, St Claire M, Reimann KA, Gabriel EE, Carrasquillo J, Reba RC, Paik C, Lane HC. JCI Insight. 2018 Jul 12;3(13).
Chronic Distress and the Vulnerable Host, a New Target for HIV Treatment and Prevention? Neurobehavioral HIV Medicine Contoreggi C. Chrousos G.P. and Di Mascio M. Neurobehavioral HIV Medicine 2016:7 1–23
Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study. Donahue RE, Srinivasula S, Uchida N, Kim I, St Claire A, Duralde G, DeGrange P, St Claire M, Reba RC, Bonifacino AC, Krouse AE, Metzger ME, Paik CH, Lane HC, Tisdale JF, Di Mascio M. Blood 2015 Dec 10;126(24):2632-41
Towards an HIV cure: a global scientific strategy.The International AIDS Society Scientific Working Group on HIV Cure, Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M., Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Lint CV, Verdin E, Woolfrey A, Zaia J, Barré-Sinoussi F. Nat Rev Immunol. 2012 Jul 20;12(8):607-614