Vaccine Research Center Senior Leadership

Deputy Director





Julie E Ledgerwood, D.O.

Julie E. Ledgerwood, D.O.

Credit
NIAID

Julie E. Ledgerwood, D.O.

Credit:
NIAID

Julie E. Ledgerwood
Deputy Director
Chief Medical Officer

Julie E. Ledgerwood, D.O., is the Deputy Director and Chief Medical Officer at the Vaccine Research Center (VRC), NIAID, NIH. She is an international expert in the areas of pandemic response, vaccine research, and clinical trial design. She has conducted more than 70 investigational clinical trials studying vaccines and monoclonal antibodies (mAbs) targeting pathogens such as HIV, influenza, Ebola, malaria, Chikungunya, Zika, and SARS-CoV-2 in over 15 countries. In her years of clinical research, Dr. Ledgerwood has authored over 120 publications in peer-reviewed journals.

She has conducted clinical research with numerous academic and biotech/pharmaceutical industry clinical research teams and has led international vaccine research collaborations for multiple infectious disease targets. Regarding HIV prevention and treatment strategy assessment, Dr. Ledgerwood has skillfully led first in human evaluations of an extensive group of broadly neutralizing human monoclonal antibodies. She also led clinical evaluation of multiple candidate Ebola vaccines and of a potent Ebola mAb (mAb114) including an Expanded Access Protocol and randomized controlled trial for treating patients in the 2018-2020 DRC Ebola outbreaks. She was part of the initial isolation of this mAb from an Ebola virus survivor, thereby being involved in the full cycle of discovery to implementation of a successful public health intervention.

For her work, Dr. Ledgerwood has received numerous awards including elected membership to the American Society for Clinical Investigation, The Politico 50: Thinkers, Doers and Visionaries Transforming American Politics in 2015, and multiple NIAID and NIH Director's awards. She serves as a member of the Clinical Infectious Diseases faculty at the NIH and as adjunct faculty for the Walter Reed National Military Medical Center Department of Allergy and Immunology. She is a graduate of Oklahoma State University College of Osteopathic Medicine, completed her residency in internal medicine at Johns Hopkins Bayview Medical Center and a fellowship in allergy and immunology at the NIH. Dr. Ledgerwood is board-certified in allergy and immunology.

 
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